Invention Grant
US08697088B2 VLPs derived from cells that do not express a viral matrix or core protein
有权
源自不表达病毒基质或核心蛋白的细胞的VLP
- Patent Title: VLPs derived from cells that do not express a viral matrix or core protein
- Patent Title (中): 源自不表达病毒基质或核心蛋白的细胞的VLP
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Application No.: US12127625Application Date: 2008-05-27
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Publication No.: US08697088B2Publication Date: 2014-04-15
- Inventor: Gale Smith , Peter Pushko , Kutub Mahmood , Bin Zhao
- Applicant: Gale Smith , Peter Pushko , Kutub Mahmood , Bin Zhao
- Applicant Address: US MD Gaithersburg
- Assignee: Novavax, Inc.
- Current Assignee: Novavax, Inc.
- Current Assignee Address: US MD Gaithersburg
- Agency: Cooley LLP
- Main IPC: A61K39/145
- IPC: A61K39/145 ; C12N15/44
Abstract:
The present invention discloses novel influenza virus-like particles (VLPs) that contain chimeric proteins or influenza membrane proteins. The chimeric proteins are derived from fragments of influenza membrane proteins fused to heterologous proteins. The invention includes antigenic formulations and vaccines comprising VLPs of the invention as well as methods of making and administering VLPs to vertebrates, including methods of inducing immunity to infections, such as influenza.
Public/Granted literature
- US20090017066A1 NOVEL VLPS DERIVED FROM CELLS THAT DO NOT EXPRESS A VIRAL MATRIX OR CORE PROTEIN Public/Granted day:2009-01-15
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