公开(公告)号：US08080255B2

公开(公告)日：2011-12-20

申请号：US11582540

申请日：2006-10-18

申请人： Gale Smith ,  Rick Bright ,  Peter Pushko ,  Jinyou Zhang ,  Kutub Mahmood

发明人： Gale Smith ,  Rick Bright ,  Peter Pushko ,  Jinyou Zhang ,  Kutub Mahmood

IPC分类号： A61K39/145

CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K39/39 ,  A61K2039/5258 ,  A61K2039/543 ,  A61K2039/55505 ,  A61K2039/55555 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/14143 ,  C12N2760/16023 ,  C12N2760/16034 ,  C12N2760/16071 ,  C12N2760/16122 ,  C12N2760/16123 ,  C12N2760/16134

摘要： The present invention discloses and claims virus like particles (VLPs) that express and/or contains seasonal influenza virus proteins, avian influenza virus proteins and/or influenza virus proteins from viruses with pandemic potential. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising VLPs of the inventions. The invention also includes methods of making and administrating VLPs to vertebrates, including methods of inducing substantial immunity to either seasonal and avian influenza, or at least one symptom thereof.

摘要翻译： 本发明公开并要求从具有大流行潜力的病毒中表达和/或含有季节性流感病毒蛋白，禽流感病毒蛋白和/或流感病毒蛋白质的病毒样颗粒（VLPs）。 本发明包括包含所述蛋白质的载体构建体，包含所述构建体的细胞，制剂和包含本发明的VLP的疫苗。 本发明还包括制备和施用VLP到脊椎动物的方法，包括诱导季节性和禽流感的实质性免疫或其至少一种症状的方法。

公开(公告)号：US08951537B2

公开(公告)日：2015-02-10

申请号：US13297125

申请日：2011-11-15

申请人： Gale Smith ,  Rick Bright ,  Peter Pushko ,  Jinyou Zhang ,  Kutub Mahmood

发明人： Gale Smith ,  Rick Bright ,  Peter Pushko ,  Jinyou Zhang ,  Kutub Mahmood

IPC分类号： A61K39/145 ,  C12N7/00 ,  C12N7/04 ,  C07K14/005 ,  C12N15/86 ,  A61K39/00

CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K39/39 ,  A61K2039/5258 ,  A61K2039/543 ,  A61K2039/55505 ,  A61K2039/55555 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/14143 ,  C12N2760/16023 ,  C12N2760/16034 ,  C12N2760/16071 ,  C12N2760/16122 ,  C12N2760/16123 ,  C12N2760/16134

摘要： The present invention discloses and claims virus like particles (VLPs) that express and/or contains seasonal influenza virus proteins, avian influenza virus proteins and/or influenza virus proteins from viruses with pandemic potential. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising VLPs of the inventions. The invention also includes methods of making and administrating VLPs to vertebrates, including methods of inducing substantial immunity to either seasonal and avian influenza, or at least one symptom thereof.

摘要翻译： 本发明公开并要求从具有大流行潜力的病毒中表达和/或含有季节性流感病毒蛋白，禽流感病毒蛋白和/或流感病毒蛋白质的病毒样颗粒（VLPs）。 本发明包括包含所述蛋白质的载体构建体，包含所述构建体的细胞，制剂和包含本发明的VLP的疫苗。 本发明还包括制备和施用VLP到脊椎动物的方法，包括诱导季节性和禽流感的实质性免疫或其至少一种症状的方法。

公开(公告)号：US20100129401A1

公开(公告)日：2010-05-27

申请号：US12340186

申请日：2008-12-19

申请人： Gale Smith ,  Rick Bright ,  Peter M. Pushko ,  Jinyou Zhang ,  Kutub Mahmood

发明人： Gale Smith ,  Rick Bright ,  Peter M. Pushko ,  Jinyou Zhang ,  Kutub Mahmood

IPC分类号： A61K39/145 ,  A61P31/16 ,  C12N7/00

CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K2039/5258 ,  A61K2039/543 ,  A61K2039/55505 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/58 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/14143 ,  C12N2760/16022 ,  C12N2760/16023 ,  C12N2760/16034 ,  C12N2760/16122 ,  C12N2760/16123 ,  C12N2760/16134

摘要： The present invention discloses and claims virus like particles (VLPs) that express and/or contains seasonal influenza virus proteins, avian influenza virus proteins and/or influenza virus proteins from viruses with pandemic potential. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising VLPs of the inventions. The invention also includes methods of making and administrating VLPs to vertebrates, including methods of inducing substantial immunity to either seasonal and avian influenza, or at least one symptom thereof.

摘要翻译： 本发明公开并要求从具有大流行潜力的病毒中表达和/或含有季节性流感病毒蛋白，禽流感病毒蛋白和/或流感病毒蛋白质的病毒样颗粒（VLPs）。 本发明包括包含所述蛋白质的载体构建体，包含所述构建体的细胞，制剂和包含本发明的VLP的疫苗。 本发明还包括制备和施用VLP到脊椎动物的方法，包括诱导季节性和禽流感的实质性免疫或其至少一种症状的方法。

公开(公告)号：US20120207786A1

公开(公告)日：2012-08-16

申请号：US13297125

申请日：2011-11-15

申请人： Gale SMITH ,  Rick Bright ,  Peter Pushko ,  Jinyou Zhang ,  Kutub Mahmood

发明人： Gale SMITH ,  Rick Bright ,  Peter Pushko ,  Jinyou Zhang ,  Kutub Mahmood

IPC分类号： A61K39/145 ,  A61P31/16

CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K39/39 ,  A61K2039/5258 ,  A61K2039/543 ,  A61K2039/55505 ,  A61K2039/55555 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/14143 ,  C12N2760/16023 ,  C12N2760/16034 ,  C12N2760/16071 ,  C12N2760/16122 ,  C12N2760/16123 ,  C12N2760/16134

摘要： The present invention discloses and claims virus like particles (VLPs) that express and/or contains seasonal influenza virus proteins, avian influenza virus proteins and/or influenza virus proteins from viruses with pandemic potential. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising VLPs of the inventions. The invention also includes methods of making and administrating VLPs to vertebrates, including methods of inducing substantial immunity to either seasonal and avian influenza, or at least one symptom thereof.

摘要翻译： 本发明公开并要求从具有大流行潜力的病毒中表达和/或含有季节性流感病毒蛋白，禽流感病毒蛋白和/或流感病毒蛋白质的病毒样颗粒（VLPs）。 本发明包括包含所述蛋白质的载体构建体，包含所述构建体的细胞，制剂和包含本发明的VLP的疫苗。 本发明还包括制备和施用VLP到脊椎动物的方法，包括诱导季节性和禽流感的实质性免疫或其至少一种症状的方法。

公开(公告)号：US20070184526A1

公开(公告)日：2007-08-09

申请号：US11582540

申请日：2006-10-18

申请人： Gale Smith ,  Rick Bright ,  Peter Pushko ,  Jinyou Zhang ,  Kutub Mahmood

发明人： Gale Smith ,  Rick Bright ,  Peter Pushko ,  Jinyou Zhang ,  Kutub Mahmood

IPC分类号： C12Q1/68 ,  C12P21/06

CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K39/39 ,  A61K2039/5258 ,  A61K2039/543 ,  A61K2039/55505 ,  A61K2039/55555 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/14143 ,  C12N2760/16023 ,  C12N2760/16034 ,  C12N2760/16071 ,  C12N2760/16122 ,  C12N2760/16123 ,  C12N2760/16134

摘要： The present invention discloses and claims virus like particles (VLPs) that express and/or contains seasonal influenza virus proteins, avian influenza virus proteins and/or influenza virus proteins from viruses with pandemic potential. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising VLPs of the inventions. The invention also includes methods of making and administrating VLPs to vertebrates, including methods of inducing substantial immunity to either seasonal and avian influenza, or at least one symptom thereof.

摘要翻译： 本发明公开并要求从具有大流行潜力的病毒中表达和/或含有季节性流感病毒蛋白，禽流感病毒蛋白和/或流感病毒蛋白质的病毒样颗粒（VLPs）。 本发明包括包含所述蛋白质的载体构建体，包含所述构建体的细胞，制剂和包含本发明的VLP的疫苗。 本发明还包括制备和施用VLP到脊椎动物的方法，包括诱导季节性和禽流感的实质性免疫或其至少一种症状的方法。

公开(公告)号：US08697088B2

公开(公告)日：2014-04-15

申请号：US12127625

申请日：2008-05-27

申请人： Gale Smith ,  Peter Pushko ,  Kutub Mahmood ,  Bin Zhao

发明人： Gale Smith ,  Peter Pushko ,  Kutub Mahmood ,  Bin Zhao

IPC分类号： A61K39/145 ,  C12N15/44

CPC分类号： A61K39/145 ,  A61K2039/5258 ,  C07K2319/00 ,  C12N7/00 ,  C12N2710/16723 ,  C12N2760/16123

摘要： The present invention discloses novel influenza virus-like particles (VLPs) that contain chimeric proteins or influenza membrane proteins. The chimeric proteins are derived from fragments of influenza membrane proteins fused to heterologous proteins. The invention includes antigenic formulations and vaccines comprising VLPs of the invention as well as methods of making and administering VLPs to vertebrates, including methods of inducing immunity to infections, such as influenza.

摘要翻译： 本发明公开了含有嵌合蛋白或流感病毒膜蛋白的新型流感病毒样颗粒（VLPs）。 嵌合蛋白质衍生自与异源蛋白质融合的流感病毒膜蛋白片段。 本发明包括抗原制剂和包含本发明的VLP的疫苗以及向脊椎动物制备和施用VLP的方法，包括诱导感染免疫的方法，例如流感。

公开(公告)号：US08506967B2

公开(公告)日：2013-08-13

申请号：US12340186

申请日：2008-12-19

申请人： Gale Smith ,  Rick Bright ,  Peter M. Pushko ,  Jinyou Zhang ,  Kutub Mahmood

发明人： Gale Smith ,  Rick Bright ,  Peter M. Pushko ,  Jinyou Zhang ,  Kutub Mahmood

IPC分类号： A61K39/145

CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K2039/5258 ,  A61K2039/543 ,  A61K2039/55505 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/58 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/14143 ,  C12N2760/16022 ,  C12N2760/16023 ,  C12N2760/16034 ,  C12N2760/16122 ,  C12N2760/16123 ,  C12N2760/16134

摘要： The present invention discloses and claims virus like particles (VLPs) that express and/or contains seasonal influenza virus proteins, avian influenza virus proteins and/or influenza virus proteins from viruses with pandemic potential. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising VLPs of the inventions. The invention also includes methods of making and administrating VLPs to vertebrates, including methods of inducing substantial immunity to either seasonal and avian influenza, or at least one symptom thereof.

公开(公告)号：US20100247574A1

公开(公告)日：2010-09-30

申请号：US12527844

申请日：2008-02-21

申请人： Kutub Mahmood ,  Gale Smith ,  Peter Pushko

发明人： Kutub Mahmood ,  Gale Smith ,  Peter Pushko

IPC分类号： A61K39/17 ,  C07K19/00 ,  A61P31/14 ,  C12P21/06

CPC分类号： C12N7/00 ,  A61K2039/5258 ,  C07K14/005 ,  C12N2710/14143 ,  C12N2760/18122 ,  C12N2760/18123 ,  Y02A50/386

摘要： The present invention discloses and claims chimeric virus like particles (VLPs) that express and/or contains Newcastle disease matrix protein. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising chimeric VLPs of the inventions. The invention also includes methods of making and administrating chimeric VLPs to vertebrates, including methods of inducing immunity to infections.

摘要翻译： 本发明公开并要求表达和/或含有新城疫基质蛋白的嵌合病毒样颗粒（VLP）。 本发明包括包含所述蛋白质的载体构建体，包含所述构建体的细胞，包含本发明的嵌合VLP的制剂和疫苗。 本发明还包括制备和给予脊椎动物嵌合VLP的方法，包括诱导感染免疫的方法。

公开(公告)号：US20090017066A1

公开(公告)日：2009-01-15

申请号：US12127625

申请日：2008-05-27

申请人： Gale Smith ,  Peter Pushko ,  Kutub Mahmood ,  Bin Zhao

发明人： Gale Smith ,  Peter Pushko ,  Kutub Mahmood ,  Bin Zhao

IPC分类号： A61K39/145 ,  C07K14/11 ,  A61P31/16 ,  C12P21/02

CPC分类号： A61K39/145 ,  A61K2039/5258 ,  C07K2319/00 ,  C12N7/00 ,  C12N2710/16723 ,  C12N2760/16123

摘要： The present invention discloses novel influenza virus-like particles (VLPs) that contain chimeric proteins or influenza membrane proteins. The chimeric proteins are derived from fragments of influenza membrane proteins fused to heterologous proteins. The invention includes antigenic formulations and vaccines comprising VLPs of the invention as well as methods of making and administering VLPs to vertebrates, including methods of inducing immunity to infections, such as influenza.

摘要翻译： 本发明公开了含有嵌合蛋白或流感病毒膜蛋白的新型流感病毒样颗粒（VLPs）。 嵌合蛋白质衍生自与异源蛋白质融合的流感病毒膜蛋白片段。 本发明包括抗原制剂和包含本发明的VLP的疫苗以及向脊椎动物制备和施用VLP的方法，包括诱导感染免疫的方法，例如流感。

公开(公告)号：US20080233150A1

公开(公告)日：2008-09-25

申请号：US11941768

申请日：2007-11-16

申请人： Gale SMITH ,  Peter Pushko ,  Mike Massare ,  Yingyun Wu ,  Kutub Mahmood

发明人： Gale SMITH ,  Peter Pushko ,  Mike Massare ,  Yingyun Wu ,  Kutub Mahmood

IPC分类号： A61K39/155 ,  A61P31/12 ,  C07K16/00

CPC分类号： A61K39/155 ,  A61K39/12 ,  A61K2039/5258 ,  C07K14/005 ,  C12N2760/18522 ,  C12N2760/18523 ,  C12N2760/18534 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/394

摘要： The present invention discloses and claims virus like particles (VLPs) that express and/or contains RSV proteins. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising VLPs of the inventions. The invention also includes methods of making and administrating VLPs to vertebrates, including methods of inducing immunity to infections, including RSV.

摘要翻译： 本发明公开并要求表达和/或含有RSV蛋白质的病毒样颗粒（VLP）。 本发明包括包含所述蛋白质的载体构建体，包含所述构建体的细胞，制剂和包含本发明的VLP的疫苗。 本发明还包括制备和施用VLP到脊椎动物的方法，包括诱导感染免疫的方法，包括RSV。