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发明授权
US08703824B2 Cationic amphiphiles with mannose-mimicking head-groups and a process for the preparation thereof 有权
具有甘露糖模拟头基的阳离子两亲物及其制备方法

Cationic amphiphiles with mannose-mimicking head-groups and a process for the preparation thereof
摘要：
The present invention discloses novel cationic amphiphiles containing mannose-mimicking shikimic and quinic acid head-groups and a process for preparing cationic amphiphiles with mannose-mimicking polar head-groups such as, shikimic and quinic acids. The findings described herein also demonstrate that compounds of the present invention can target model DNA vaccines to antigen presenting cells (APCs) such as macrophages and dendritic cells (DCs), via mannose receptors expressed on the cell surface of APCs. The cationic amphiphiles disclosed herein show enhanced cellular and humoral immune response compared to their mannosyl counterpart in dendritic cell (DC, the most professional APC) based genetic immunization in mice. Cationic amphiphiles with mannose-mimicking quinic and shikimic acid head-groups described in the present invention are likely to find future applications in the field of genetic immunization.
摘要（中）：

本发明公开了含有甘露糖模拟莽草酸和奎尼酸头基的新型阳离子两亲物和用甘露糖模拟极性头基如莽草酸和奎尼酸制备阳离子两亲物的方法。 本文所述的发现还证明本发明的化合物可以通过在APC的细胞表面上表达的甘露糖受体将模拟DNA疫苗靶向抗原呈递细胞（APCs）如巨噬细胞和树突状细胞（DC）。 本文公开的阳离子两亲物与其在小鼠中的树突状细胞（DC，最专业的APC）基于遗传免疫的它们的甘露糖基配对相比显示出增强的细胞和体液免疫应答。 本发明中描述的具有甘露糖模拟奎尼克酸和莽草酸头团的阳离子两亲物可能在遗传免疫领域中找到未来的应用。

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