发明授权
US08715638B2 Ethenyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections
有权
乙烯基取代的吡啶和嘧啶衍生物及其在治疗病毒感染中的应用
- 专利标题： Ethenyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections
- 专利标题（中）： 乙烯基取代的吡啶和嘧啶衍生物及其在治疗病毒感染中的应用
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申请号： US13059199申请日： 2009-08-19
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公开(公告)号： US08715638B2公开(公告)日： 2014-05-06
- 发明人: Cecil D. Kwong , F. George Njoroge , Subramaniam Ananthan , Jeremy Clark , Feng Geng , Hollis S. Kezar, III , Joseph A. Maddry , John J. Piwinski , Robert C. Reynolds , Abhijit Roychowdhury , John A. Secrist, III , Neng-Yang Shih
- 申请人： Cecil D. Kwong , F. George Njoroge , Subramaniam Ananthan , Jeremy Clark , Feng Geng , Hollis S. Kezar, III , Joseph A. Maddry , John J. Piwinski , Robert C. Reynolds , Abhijit Roychowdhury , John A. Secrist, III , Neng-Yang Shih
- 申请人地址： US NJ Rahway US AL Birmingham
- 专利权人： Merck Sharp & Dohme Corp.,Southern Research Institute
- 当前专利权人： Merck Sharp & Dohme Corp.,Southern Research Institute
- 当前专利权人地址： US NJ Rahway US AL Birmingham
- 代理商 Carol S. Quagliato; Sheldon O. Heber
- 国际申请： PCT/US2009/054271 WO 20090819
- 国际公布： WO2010/022128 WO 20100225
- 主分类号： A61K31/505
- IPC分类号： A61K31/505 ; A61K38/21 ; A61K39/42 ; C07D239/02
摘要：
The present invention provides compounds of Formula (A): (Chemical formula should be inserted here as it appears on abstract in paper form) (A) and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein wherein each of R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19, R22, R23, and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders.
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