摘要:
The disclosed invention provides compositions and methods of treating a Flaviviridae infection, including hepatitis C virus, West Nile Virus, yellow fever virus, and a rhinovirus infection in a host, including animals, and especially humans, using a (2′R)-2′-deoxy-2′-fluoro-2′-C-methyl nucleosides, or a pharmaceutically acceptable salt or prodrug thereof.
摘要:
The present invention provides compounds of Formula (A): (Chemical formula should be inserted here as it appears on abstract in paper form) (A) and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein wherein each of R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19, R22, R23, and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders.
摘要:
The disclosed invention provides compositions and methods of treating a Flaviviridae infection, including hepatitis C virus, West Nile Virus, yellow fever virus, and a rhinovirus infection in a host, including animals, and especially humans, using a (2′R)-2′-deoxy-2′-fluoro-2′-C-methyl nucleosides, or a pharmaceutically acceptable salt or prodrug thereof.
摘要:
A retail display article based upon an original photograph of a subject including at least one item of clothing and having visible portions of skin. The display article includes a back panel and a display photograph. The back panel defines a flat surface. The display photograph depicts an edited version of the original photograph such that the visible portions of skin depicted in the display photograph is configured to imitate a general appearance of a mannequin. The display photograph is disposed on the flat surface of the back panel. The display photograph and the back panel are collectively cut about the perimeter of the subject. Retail display systems and methods of construction provide additional advantages.
摘要:
This invention relates to the histone acetyl transferase protein HBO1 and its use in diagnosis and therapy of breast cancers. Methods and means relating to the diagnosis and treatment of breast cancer are provided.
摘要:
The disclosed invention provides compositions and methods of treating a Flaviviridae infection, including hepatitis C virus, West Nile Virus, yellow fever virus, and a rhinovirus infection in a host, including animals, and especially humans, using a (2′R)-2′-deoxy-2′-fluoro-2′-C-methyl nucleosides, or a pharmaceutically acceptable salt or prodrug thereof.
摘要:
The present invention provides compounds of Formula (I): and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein each of R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19 and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders.
摘要:
The disclosed invention provides compositions and methods of treating a Flaviviridae infection, including hepatitis C virus, West Nile Virus, yellow fever virus, and a rhinovirus infection in a host, including animals, and especially humans, using a (2′R)-2′-deoxy-2′-fluoro-2′-C-methyl nucleosides, or a pharmaceutically acceptable salt or prodrug thereof.
摘要:
Compounds having the formula I wherein R1 is as herein defined are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for inhibiting hepatitis replication, and processes for making the compounds of formula I
摘要:
This invention relates to an electronic ringing circuit for telephone systems. The inventive circuit provides a dual tone output with the tones changing at a predetermined rate. The circuit consists of a rectifying circuit connected across the telephone lines which receive the normal 90VAC/20 Hz telephone ringing signals. The rectified signal is then connected to one input terminal of a voltage comparator, the other terminal of which is connected to a reference voltage source. When a ringing signal is present, the rectified signal will be greater than the voltage of the reference source so that the voltage comparator will provide an output. This output is fed to the control terminals of electronically controlled switches, and when the switches are closed, the oscillators will be grounded through frequency determining capacitors associated with the respective oscillators. In addition, associated with one of the oscillators is a second electronically controlled switch and a second frequency determining capacitor. The control terminal of the second switch is connected to the output of the other one of the oscillators. Thus, when a ringing signal comes over the telephone lines, both of the oscillators will be turned on. The second oscillator will switch in the second frequency determining capacitor at a predetermined rate, so that the output of the one oscillator will change at this predetermined rate to thereby provide a multi-tone signal. The output of the one oscillator is fed to a speaker.