Invention Grant
- Patent Title: Chimeric west nile/dengue viruses
- Patent Title (中): 嵌合西尼罗河/登革热病毒
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Application No.: US12990322Application Date: 2009-04-27
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Publication No.: US08715689B2Publication Date: 2014-05-06
- Inventor: Claire Y. H. Kinney , Eric Thomas Beck , Richard M. Kinney
- Applicant: Claire Y. H. Kinney , Eric Thomas Beck , Richard M. Kinney
- Applicant Address: US GA Atlanta
- Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention
- Current Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention
- Current Assignee Address: US GA Atlanta
- Agency: Klarquist Sparkman, LLP
- International Application: PCT/US2009/041824 WO 20090427
- International Announcement: WO2009/134717 WO 20091105
- Main IPC: A61K39/295
- IPC: A61K39/295 ; A61K48/00
Abstract:
The disclosure provides chimeric West Nile/Dengue viruses comprising non-coding regions, non-structural proteins, and a C protein from a West Nile virus and prM and E proteins from a Dengue virus. Also disclosed are methods of using the chimeric viruses in diagnosis of Dengue viral infection, assessment of candidate Dengue virus vaccine efficacy, and production of Dengue prM and E proteins.
Public/Granted literature
- US20110150771A1 CHIMERIC WEST NILE/DENGUE VIRUSES Public/Granted day:2011-06-23
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