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公开(公告)号：US09169298B2
公开(公告)日：2015-10-27
申请号：US13281240
申请日：2011-10-25
申请人： Richard Kinney , Claire Y. H. Kinney , Véronique Barban , Jean Lang , Bruno Guy
发明人： Richard Kinney , Claire Y. H. Kinney , Véronique Barban , Jean Lang , Bruno Guy
IPC分类号： A61K39/12 , C07K14/005 , C12N7/00 , A61K39/00
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5254 , A61K2039/545 , C12N7/00 , C12N2770/24121 , C12N2770/24122 , C12N2770/24134 , C12N2770/24164 , Y02A50/386
摘要： The invention relates to live attenuated VDV1 (VERO-Derived Dengue serotype 1 virus) strains which have been derived from the wild-type dengue-1 strain 16007 by passaging on PDK and sanitization on Vero cells and nucleic acids thereof. The invention further relates to a vaccine composition which comprises a VDV1 strain.
摘要翻译： 本发明涉及通过传代PDK并通过Vero细胞和其核酸消毒而衍生自野生型登革热-1菌株16007的活减毒VDV1（VERO-衍生登革热血清型1病毒）菌株。 本发明还涉及包含VDV1菌株的疫苗组合物。
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公开(公告)号：US08067566B2
公开(公告)日：2011-11-29
申请号：US12633459
申请日：2009-12-08
申请人： Richard Kinney , Claire Y. H. Kinney , Véronique Barban , Jean Lang , Bruno Guy
发明人： Richard Kinney , Claire Y. H. Kinney , Véronique Barban , Jean Lang , Bruno Guy
IPC分类号： A61K39/12
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5254 , C12N7/00 , C12N2770/24122 , C12N2770/24134 , C12N2770/24164 , Y02A50/386
摘要： The invention relates to live attenuated VDV2 (VERO-Derived Vaccine Dengue serotype 2) strains which have been derived from the wild-type dengue-2 strain 16681 by passaging on PDK and Vero cells and nucleic acids thereof. The invention further relates to a vaccine composition which comprises a VDV2 strain.
摘要翻译： 本发明涉及通过传代PDK和Vero细胞及其核酸而衍生自野生型登革热-2菌株16681的活减毒VDV2（VERO-衍生疫苗登革热血清型2）菌株。 本发明还涉及包含VDV2菌株的疫苗组合物。
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公开(公告)号：US07641909B2
公开(公告)日：2010-01-05
申请号：US11506251
申请日：2006-08-18
申请人： Richard M. Kinney , Claire Y. H. Kinney , Duane J. Gubler , Siritorn Butrapet , Natth Bhamarapravati
发明人： Richard M. Kinney , Claire Y. H. Kinney , Duane J. Gubler , Siritorn Butrapet , Natth Bhamarapravati
IPC分类号： A61K39/00 , A61K39/13 , A61K39/295 , C12N15/63
CPC分类号： A61K39/12 , A61K39/295 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2770/24121 , C12N2770/24122 , C12N2770/24134 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： Chimeric flaviviruses that are avirulent and immunogenic are provided. The chimeric viruses are constructed to contain amino acid mutations in the nonstructural proteins of a flavivirus. Chimeric viruses containing the attenuation-mutated nonstructural genes of the virus are used as a backbone into which the structural protein genes of a second flavivirus strain are inserted. These chimeric viruses elicit pronounced immunogenicity yet lack the accompanying clinical symptoms of viral disease. The attenuated chimeric viruses are effective as immunogens or vaccines and may be combined in a pharmaceutical composition to confer simultaneous immunity against several strains of pathogenic flaviviruses.
摘要翻译： 提供无毒和免疫原性的嵌合黄病毒。 构建嵌合病毒以在黄病毒的非结构蛋白中含有氨基酸突变。 含有病毒衰减突变非结构基因的嵌合病毒被用作插入第二种黄病毒毒株的结构蛋白基因的骨架。 这些嵌合病毒引起显着的免疫原性，但缺乏伴随的病毒性疾病的临床症状。 减毒的嵌合病毒作为免疫原或疫苗是有效的，并且可以在药物组合物中组合以赋予多种病原性黄病毒的同时免疫。
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公开(公告)号：US07641908B2
公开(公告)日：2010-01-05
申请号：US11453344
申请日：2006-06-15
申请人： Richard Kinney , Claire Y. H. Kinney , Véronique Barban , Jean Lang , Bruno Guy
发明人： Richard Kinney , Claire Y. H. Kinney , Véronique Barban , Jean Lang , Bruno Guy
IPC分类号： A61K39/12
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5254 , C12N7/00 , C12N2770/24122 , C12N2770/24134 , C12N2770/24164 , Y02A50/386
摘要： The invention relates to live attenuated VDV2 (VERO-Derived Vaccine Dengue serotype 2) strains which have been derived from the wild-type dengue-2 strain 16681 by passaging on PDK and Vero cells. The invention further relates to a vaccine composition which comprises a VDV2 strain.
摘要翻译： 本发明涉及通过传代PDK和Vero细胞从野生型登革热-2菌株16681衍生的活的减毒VDV2（VERO-衍生疫苗登革热血清型2）菌株。 本发明还涉及包含VDV2菌株的疫苗组合物。
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公开(公告)号：US08673316B2
公开(公告)日：2014-03-18
申请号：US13212845
申请日：2011-08-18
申请人： Richard M. Kinney , Claire Y. H. Kinney , Duane J. Gubler , Siritorn Butrapet , Natth Bhamarapravati
发明人： Richard M. Kinney , Claire Y. H. Kinney , Duane J. Gubler , Siritorn Butrapet , Natth Bhamarapravati
IPC分类号： A61K39/12 , A61K35/00 , A61K39/295 , C12N15/63
CPC分类号： A61K39/12 , A61K39/295 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2770/24121 , C12N2770/24122 , C12N2770/24134 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： Chimeric flaviviruses that are avirulent and immunogenic are provided. The chimeric viruses are constructed to contain amino acid mutations in the nonstructural viral proteins of a flavivirus. Chimeric viruses containing the attenuation-mutated nonstructural genes of the virus are used as a backbone into which the structural genes of a second flavivirus strain are inserted. These chimeric viruses elicit pronounced immunogenicity yet lack the accompanying clinical symptoms of viral disease. The attenuated chimeric viruses are effective as immunogens or vaccines and may be combined in a pharmaceutical composition to confer simultaneous immunity against several strains of pathogenic flaviviruses.
摘要翻译： 提供无毒和免疫原性的嵌合黄病毒。 构建嵌合病毒以在黄病毒的非结构病毒蛋白中含有氨基酸突变。 含有病毒的衰减突变非结构基因的嵌合病毒被用作插入第二种黄病毒毒株的结构基因的主链。 这些嵌合病毒引起显着的免疫原性，但缺乏伴随的病毒性疾病的临床症状。 减毒的嵌合病毒作为免疫原或疫苗是有效的，并且可以在药物组合物中组合以赋予多种病原性黄病毒的同时免疫。
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公开(公告)号：US08025887B2
公开(公告)日：2011-09-27
申请号：US12607746
申请日：2009-10-28
申请人： Richard M. Kinney , Claire Y. H. Kinney , Duane J. Gubler , Siritorn Butrapet , Natth Bhamarapravati
发明人： Richard M. Kinney , Claire Y. H. Kinney , Duane J. Gubler , Siritorn Butrapet , Natth Bhamarapravati
CPC分类号： A61K39/12 , A61K39/295 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2770/24121 , C12N2770/24122 , C12N2770/24134 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： Chimeric flaviviruses that are avirulent and immunogenic are provided. The chimeric viruses are constructed to contain amino acid mutations in the nonstructural viral proteins of a flavivirus. Chimeric viruses containing the attenuation-mutated nonstructural genes of the virus are used as a backbone into which the structural genes of a second flavivirus strain are inserted. These chimeric viruses elicit pronounced immunogenicity yet lack the accompanying clinical symptoms of viral disease. The attenuated chimeric viruses are effective as immunogens or vaccines and may be combined in a pharmaceutical composition to confer simultaneous immunity against several strains of pathogenic flaviviruses.
摘要翻译： 提供无毒和免疫原性的嵌合黄病毒。 构建嵌合病毒以在黄病毒的非结构病毒蛋白中含有氨基酸突变。 含有病毒的衰减突变非结构基因的嵌合病毒被用作插入第二种黄病毒毒株的结构基因的主链。 这些嵌合病毒引起显着的免疫原性，但缺乏伴随的病毒性疾病的临床症状。 减毒的嵌合病毒作为免疫原或疫苗是有效的，并且可以在药物组合物中组合以赋予多种病原性黄病毒的同时免疫。
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公开(公告)号：US08795688B2
公开(公告)日：2014-08-05
申请号：US13281255
申请日：2011-10-25
申请人： Richard Kinney , Claire Y. H. Kinney , Véronique Barban , Jean Lang , Bruno Guy
发明人： Richard Kinney , Claire Y. H. Kinney , Véronique Barban , Jean Lang , Bruno Guy
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5254 , C12N7/00 , C12N2770/24122 , C12N2770/24134 , C12N2770/24164 , Y02A50/386
摘要： The invention relates to live attenuated VDV2 (VERO-Derived Vaccine Dengue serotype 2) strains which have been derived from the wild-type dengue-2 strain 16681 by passaging on PDK and Vero cells and nucleic acids thereof. The invention further relates to a vaccine composition which comprises a VDV2 strain.
摘要翻译： 本发明涉及通过传代PDK和Vero细胞及其核酸而衍生自野生型登革热-2菌株16681的活减毒VDV2（VERO-衍生疫苗登革热血清型2）菌株。 本发明还涉及包含VDV2菌株的疫苗组合物。
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公开(公告)号：US08067565B2
公开(公告)日：2011-11-29
申请号：US12633411
申请日：2009-12-08
申请人： Richard Kinney , Claire Y. H. Kinney , Véronique Barban , Jean Lang , Bruno Guy
发明人： Richard Kinney , Claire Y. H. Kinney , Véronique Barban , Jean Lang , Bruno Guy
IPC分类号： A61K39/12
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5254 , A61K2039/545 , C12N7/00 , C12N2770/24121 , C12N2770/24122 , C12N2770/24134 , C12N2770/24164 , Y02A50/386
摘要： The invention relates to live attenuated VDV1 (VERO-Derived Dengue serotype 1 virus) strains which have been derived from the wild-type dengue-1 strain 16007 by passaging on PDK and sanitization on Vero cells and nucleic acids thereof. The invention further relates to a vaccine composition which comprises a VDV1 strain.
摘要翻译： 本发明涉及通过传代PDK并通过Vero细胞和其核酸消毒而衍生自野生型登革热-1菌株16007的活减毒VDV1（VERO-衍生登革热血清型1病毒）菌株。 本发明还涉及包含VDV1菌株的疫苗组合物。
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公开(公告)号：US08715689B2
公开(公告)日：2014-05-06
申请号：US12990322
申请日：2009-04-27
IPC分类号： A61K39/295 , A61K48/00
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5256 , A61K2039/53 , A61K2039/70 , C07K14/005 , C12N2770/24122 , C12N2770/24134 , C12N2770/24162 , Y02A50/386 , Y02A50/394
摘要： The disclosure provides chimeric West Nile/Dengue viruses comprising non-coding regions, non-structural proteins, and a C protein from a West Nile virus and prM and E proteins from a Dengue virus. Also disclosed are methods of using the chimeric viruses in diagnosis of Dengue viral infection, assessment of candidate Dengue virus vaccine efficacy, and production of Dengue prM and E proteins.
摘要翻译： 本公开提供了包含非编码区，非结构蛋白和来自西尼罗河病毒的C蛋白和来自登革病毒的prM和E蛋白的嵌合西尼罗河/登革病毒。 还公开了使用嵌合病毒诊断登革热病毒感染，评估候选登革热病毒疫苗功效以及登革热prM和E蛋白的产生的方法。
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公开(公告)号：US07641907B2
公开(公告)日：2010-01-05
申请号：US11449876
申请日：2006-06-09
申请人： Richard Kinney , Claire Y. H. Kinney , Véronique Barban , Jean Lang , Bruno Guy
发明人： Richard Kinney , Claire Y. H. Kinney , Véronique Barban , Jean Lang , Bruno Guy
IPC分类号： A61K39/12
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5254 , A61K2039/545 , C12N7/00 , C12N2770/24121 , C12N2770/24122 , C12N2770/24134 , C12N2770/24164 , Y02A50/386
摘要： The invention relates to live attenuated VDV1 (VERO-Derived Dengue serotype 1 virus) strains which have been derived from the wild-type dengue-1 strain 16007 by passaging on PDK and sanitization on Vero cells. The invention further relates to a vaccine composition which comprises a VDV1 strain.
摘要翻译： 本发明涉及通过传代PDK并在Vero细胞上消毒而衍生自野生型登革热-1型菌株16007的活减毒VDV1（VERO-衍生登革热血清型1病毒）菌株。 本发明还涉及包含VDV1菌株的疫苗组合物。
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