发明授权
- 专利标题： Inhibitors of diacylglycerol acyltransferase
- 专利标题（中）： 二酰基甘油酰基转移酶抑制剂
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申请号： US13129843申请日： 2009-11-17
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公开(公告)号： US08716312B2公开(公告)日： 2014-05-06
- 发明人: Pauline C. Ting , Robert Aslanian , Mary Ann Caplen , Jianhua Cao , Tin-Yau Chan , David Kim , Hyunjin Kim , Jae-Hun Kim , Rongze Kuang , Joe F. Lee , John Schwerdt , Heping Wu , Nicolas Zorn
- 申请人： Pauline C. Ting , Robert Aslanian , Mary Ann Caplen , Jianhua Cao , Tin-Yau Chan , David Kim , Hyunjin Kim , Jae-Hun Kim , Rongze Kuang , Joe F. Lee , John Schwerdt , Heping Wu , Nicolas Zorn
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corporation
- 当前专利权人： Merck Sharp & Dohme Corporation
- 当前专利权人地址： US NJ Rahway
- 代理商 Kenrick L. Vidale; Janet E. Fair; Anna L. Cocuzzo
- 国际申请： PCT/US2009/064738 WO 20091117
- 国际公布： WO2010/059602 WO 20100527
- 主分类号： A61P3/00
- IPC分类号： A61P3/00 ; A61P9/00 ; A61K31/445 ; C07D413/12 ; C07D413/14 ; C07D417/12 ; C07D417/14
摘要：
The present invention relates to novel heterocyclic compounds as diacylglycerol acyltransferase (“DGAT”) inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventing a cardiovascular disease, a metabolic disorder, obesity or an obesity-related disorder, diabetes, dyslipidemia, a diabetic complication, impaired glucose tolerance or impaired fasting glucose. An illustrative compound of the invention is shown below:
公开/授权文献
- US20110224137A1 INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE 公开/授权日：2011-09-15