A toothbrush and flossing system comprising a toothbrush having bristles, a handle, and a removable floss cartridge/container. The handle may comprise a cavity for receiving the floss cartridge; the floss container may comprise all or a portion of the handle; or the floss container may slip externally over the toothbrush handle. The floss cartridge may comprise a housing having a closed end and an open end, with a cap adapted to seal the open end and to protrude from the housing and the cavity with a recessed cutter separated from a floss exit opening in the cap. The cap may have a decorative design, such as in the form of a human, animal, cartoon character, or the like. In another embodiment, an ornamental enclosure is provided that attaches to the handle. Toothbrush embodiments for receiving the floss cartridge and floss cartridge embodiments for use with such toothbrushes are also claimed.