发明授权
- 专利标题： Inhibitors of bruton's tyrosine kinase
- 专利标题（中）： 布鲁特酪氨酸激酶抑制剂
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申请号： US13472541申请日： 2012-05-16
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公开(公告)号： US08729078B2公开(公告)日： 2014-05-20
- 发明人: Roland Joseph Billedeau , Rama K. Kondru , Francisco Javier Lopez-Tapia , Yan Lou , Timothy D. Owens , Yimin Qian , Sung-Sau So , Kshitij C. Thakkar , Jutta Wanner , Omar Jose Morales
- 申请人： Roland Joseph Billedeau , Rama K. Kondru , Francisco Javier Lopez-Tapia , Yan Lou , Timothy D. Owens , Yimin Qian , Sung-Sau So , Kshitij C. Thakkar , Jutta Wanner , Omar Jose Morales
- 申请人地址： US NJ Nutley
- 专利权人： Hoffmann-La Roche Inc.
- 当前专利权人： Hoffmann-La Roche Inc.
- 当前专利权人地址： US NJ Nutley
- 主分类号： A01N43/58
- IPC分类号： A01N43/58 ; A61K31/50 ; C07D237/00
摘要：
This application discloses compounds according to generic Formula I: wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.
公开/授权文献
- US20120295885A1 INHIBITORS OF BRUTON'S TYROSINE KINASE 公开/授权日：2012-11-22
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