A chip includes a first circuit, a second circuit, a first interconnect, and a least one protection circuit. The first circuit has a first node, a first operational voltage node, and a first reference voltage node. The second circuit has a second node, a second operational voltage node, and a second reference voltage node. The first interconnect is configured to electrically connect the first node and the second node to form a 2.5D or a 3D integrated circuit. The at least one protection circuit is located at one or various locations of the chip.