发明授权
- 专利标题: Benzamide compounds useful as histone deacetylase inhibitors
- 专利标题(中): 可用作组蛋白脱乙酰酶抑制剂的苯甲酰胺化合物
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申请号: US13472095申请日: 2012-05-15
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公开(公告)号: US08735429B2公开(公告)日: 2014-05-27
- 发明人: David Michael Andrews , Elaine Sophie Elizabeth Stokes , Andrew Turner , Michael James Waring
- 申请人: David Michael Andrews , Elaine Sophie Elizabeth Stokes , Andrew Turner , Michael James Waring
- 申请人地址: SE Sodertalje
- 专利权人: AstraZeneca AB
- 当前专利权人: AstraZeneca AB
- 当前专利权人地址: SE Sodertalje
- 优先权: GB0521244.4 20051019
- 主分类号: A61K31/445
- IPC分类号: A61K31/445
摘要:
The invention concerns benzamide compounds of formula (I): compound of formula (I): wherein R1 is a C-linked pyrazole ring, which is optionally substituted by one or more groups selected from C1-4alkyl, C3-4cycloalkyl, C1-4alkoxy and C3-4cycloalkoxy; or a pharmaceutically acceptable salt or pro-drug form thereof. The invention also concerns processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumors or other proliferative conditions, which are sensitive to the inhibition of histone deacetylase (HDAC).
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