Invention Grant
- Patent Title: HIV-1 clade a consensus sequences, antigens, and transgenes
- Patent Title (中): HIV-1携带共有序列,抗原和转基因
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Application No.: US13398897Application Date: 2012-02-17
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Publication No.: US08735542B2Publication Date: 2014-05-27
- Inventor: Kalpana Gupta , Nicholas Jackson
- Applicant: Kalpana Gupta , Nicholas Jackson
- Applicant Address: US NY New York
- Assignee: International AIDS Vaccine Initiative
- Current Assignee: International AIDS Vaccine Initiative
- Current Assignee Address: US NY New York
- Agency: Vedder Price P.C.
- Agent Thomas J. Kowalski; Deborah L. Lu
- Main IPC: C07K1/00
- IPC: C07K1/00 ; A61K38/00 ; A61K38/16 ; A61K39/00 ; A61K39/12 ; A61K39/21

Abstract:
The present invention relates to consensus nucleotide and protein sequences for HIV-1 Clade A antigens, and to nucleotide and protein sequences for Clade A antigens from circulating HIV-1 field isolates wherein the antigen sequences are closely related to the these consensus sequences. Advantageously, the present invention relates to HIV-1 Clade A transgenes that are derived from such sequences, and that encode either HIV-1 Clade A Gag, Pol (RT and Int), and Nef (collectively “GRIN”), HIV-1 Clade A Gag, RT, and Nef (collectively “GRN”), or HIV-1 Clade A Env. The invention also relates to vectors containing such transgenes, including adenovirus vectors containing such transgenes. The invention also relates to immunogenic compositions comprising the HIV-1 Clade A antigens, nucleotide sequences, vectors, or transgenes of the invention, and to methods of generating an immune response against HIV in a subject by administering an effective amount of such immunogenic compositions.
Public/Granted literature
- US20120219577A1 HIV-1 CLADE A CONSENSUS SEQUENCES, ANTIGENS, AND TRANSGENES Public/Granted day:2012-08-30
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