发明授权
- 专利标题： Pegylated albumin and uses thereof
- 专利标题（中）： 聚乙二醇化白蛋白及其用途
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申请号： US11921064申请日： 2006-06-09
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公开(公告)号： US08741832B2公开(公告)日： 2014-06-03
- 发明人: Seetharama A. Acharya , Belur N. Manjula
- 申请人： Seetharama A. Acharya , Belur N. Manjula
- 申请人地址： US NY Bronx
- 专利权人： Albert Einstein College of Medicine of Yeshiva University
- 当前专利权人： Albert Einstein College of Medicine of Yeshiva University
- 当前专利权人地址： US NY Bronx
- 代理机构： Amster, Rothstein & Ebenstein LLP
- 国际申请： PCT/US2006/022463 WO 20060609
- 国际公布： WO2006/135740 WO 20061221
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07K1/00 ; C07K14/00 ; C07K16/00 ; C07K17/00 ; C07K14/76 ; C07K14/805
摘要：
The present invention provides PEGylated hemoglobins and PEGylated albumins comprising polyethylene glycol (PEG) conjugated to hemoglobin or to albumin, wherein the PEG is a maleimide PEG, an alkylamide PEG, an iodoacetamide PEG, a p-nitro thio-phenyl PEG, a vinyl sulfone PEG, or a mixed disulfide PEG; and PEGylated albumins and PEGylated hemoglobins comprising polyethylene glycol (PEG) attached to a thiolated amino group of albumin or hemoglobin, wherein the amino group is thiolated using dithio sulfo succinimidyl propionate (DTSSP) or dithiosuccinimidyl propionate (DTSP) or dithiobispropionimidate. The invention also provides methods of preparing PEGylated hemoglobins and PEGylated albumins comprising a) reacting hemoglobin or albumin with a thiolating agent and with a PEGylating agent, and b) capping unPEGylated reactive thiols of hemoglobin or albumin with N-ethyl maleimide.
公开/授权文献
- US20090298746A1 Pegylated hemoglobin and albumin and uses thereof 公开/授权日：2009-12-03
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