发明授权
- 专利标题： Organic compound for the regulation of vectorial ion channels
- 专利标题（中）： 用于调节载体离子通道的有机化合物
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申请号： US13522204申请日： 2011-01-12
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公开(公告)号： US08754049B2公开(公告)日： 2014-06-17
- 发明人: Bernhard Fischer , Rudolf Lucas , Susan Tzotzos
- 申请人： Bernhard Fischer , Rudolf Lucas , Susan Tzotzos
- 申请人地址： AT Vienna
- 专利权人： APEPTICO Forschung und Entwicklung GmbH
- 当前专利权人： APEPTICO Forschung und Entwicklung GmbH
- 当前专利权人地址： AT Vienna
- 代理商 D. Peter Hochberg; Sean F. Mellino; Richard A. Wolf
- 优先权： ATA41/2010 20100114
- 国际申请： PCT/AT2011/000014 WO 20110112
- 国际公布： WO2011/085423 WO 20110721
- 主分类号： A61K38/12
- IPC分类号： A61K38/12 ; A61K38/00 ; A61K38/16 ; A61K38/10 ; A61K38/04 ; A61P11/00 ; C07K5/00 ; C07K7/00 ; C07K16/00 ; C07K17/00
摘要：
A cyclic organic compound which comprises 16 amino acids or 17 amino acids and has no carboxyl group C-terminally and/or no amino group N-terminally. Optionally, one of the amino acids is a nonnatural amino acid. The ring closure is formed between a side chain of one amino acid and the C-terminus of another amino acid, or the ring closure is effected with the aid of a nonnatural amino acid. A process for producing and using the compound for regulating vectorial ion channels, for treating diseases associated with the lung function and for treating oedemas is provided.
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