An injection port system comprises an injection port and an applier. The port comprises a body and a plurality of fasteners. The fasteners are integral with the body and are movable from a non-deployed position to a deployed position. The applier comprises a port engagement portion and an actuator. The port engagement portion is configured to selectively engage the port body to selectively retain the port relative to the applier. The actuator is operable to move the fasteners to the deployed position. The applier is also configured to disengage the port engagement portion from the port body to release the port from the applier when the actuator moves the fasteners to the deployed position. The actuator may release the port from the applier by moving a resilient member away from the port body as the actuator also moves the fasteners from the non-deployed position to the deployed position.