发明授权
US08758822B2 Method for manufacturing uniform size polymeric nanoparticles containing poorly soluble drugs
有权
制备均匀尺寸的含有难溶性药物的聚合物纳米颗粒的方法
- 专利标题: Method for manufacturing uniform size polymeric nanoparticles containing poorly soluble drugs
- 专利标题(中): 制备均匀尺寸的含有难溶性药物的聚合物纳米颗粒的方法
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申请号: US12990540申请日: 2009-04-30
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公开(公告)号: US08758822B2公开(公告)日: 2014-06-24
- 发明人: Bong Hyun Chung , Yong Taik Lim , Jung Hyun Han
- 申请人: Bong Hyun Chung , Yong Taik Lim , Jung Hyun Han
- 申请人地址: KR Daejeon
- 专利权人: Korea Research Institute of Bioscience and Biotechnology
- 当前专利权人: Korea Research Institute of Bioscience and Biotechnology
- 当前专利权人地址: KR Daejeon
- 代理机构: Lucas & Mercanti, LLP
- 优先权: KR10-2008-0041017 20080501
- 国际申请: PCT/KR2009/002289 WO 20090430
- 国际公布: WO2009/134091 WO 20091105
- 主分类号: A61K9/14
- IPC分类号: A61K9/14 ; A61K38/00 ; A61K38/36 ; A61K38/13 ; A01N45/00 ; A61K31/56 ; A61K31/585 ; A61K31/54 ; A61K31/505 ; A61K31/095 ; A61K31/045 ; B01D61/00 ; A61K9/16 ; C08J3/03 ; B01D65/00
摘要:
The present invention relates to a method for manufacturing uniform size polymeric nanoparticles containing poorly soluble drugs, and more particularly, to a method for manufacturing uniform size polymeric nanoparticles containing poorly soluble drugs, including a first step of dissolving a biodegradable polymer in a non-volatile polar organic solvent, a second step of adding poorly soluble drugs to water and the biodegradable polymer solution to produce a dispersion, and a third step of adding the dispersion to emulsifier solutions in a batch under the condition of low mechanical energy level stirring. The polymeric nanoparticles of the present invention is capable of manufacturing nano-sized small and uniform polymeric nanoparticles through a simple method of employing a non-volatile polar solvent, especially a solvent having a polarity similar to that of water, as a solvent for a mixture solution of biodegradable polymer and poorly soluble materials, and using a low mechanical energy condition and batch-adding of dispersion in an emulsifying process. The polymeric nanoparticles of the present invention are advantageous in that the dissolution rate of the poorly soluble drugs contained in polymeric particles is dramatically improved, and the poorly soluble drugs are gradually and steadily released and maintained at a constant density over a long period of time.
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