发明授权
US08759518B2 Intermediates for the preparation of HMG CoA reductase inhibitors and processes for the preparation thereof
失效
用于制备HMG CoA还原酶抑制剂的中间体及其制备方法
- 专利标题: Intermediates for the preparation of HMG CoA reductase inhibitors and processes for the preparation thereof
- 专利标题(中): 用于制备HMG CoA还原酶抑制剂的中间体及其制备方法
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申请号: US13576296申请日: 2011-02-23
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公开(公告)号: US08759518B2公开(公告)日: 2014-06-24
- 发明人: Shriprakash Dhar Dwivedi , Dhimant Jasubhai Patel , Mahesh Laljibhai Rupapara
- 申请人: Shriprakash Dhar Dwivedi , Dhimant Jasubhai Patel , Mahesh Laljibhai Rupapara
- 申请人地址: IN Ahmedabad
- 专利权人: Cadila Healthcare Limited
- 当前专利权人: Cadila Healthcare Limited
- 当前专利权人地址: IN Ahmedabad
- 代理机构: Ladas & Parry LLP
- 优先权: IN481/MUM/2010 20100223; IN1820/MUM2010 20100617
- 国际申请: PCT/IN2011/000108 WO 20110223
- 国际公布: WO2011/104725 WO 20110901
- 主分类号: C07D239/02
- IPC分类号: C07D239/02 ; C07D405/12 ; C07D239/42 ; C07D405/06 ; C07D257/04
摘要:
A compound of Formula (1), is disclosed wherein P1 and P2 are alcohol protecting groups or 1,3-diol protecting group, R is selected from: wherein R4a is selected from alkyl, aryl, arylalkyl and cycloalkyl, Rc is selected from H, alkyl, aryl, alkaoxy, haloalkyl, monohaloalkyloxy, and dihaloalkyloxy, Rd is selected from alkyl, aryl, arylalkyl, CF3, halo and NO2 and X is selected from O, N—H, N-alkyl and S, Ra and Rb are same or different and each represents hydrogen, an alkyl group of 1 to 12 carbon atoms, an aryl group of 6 to 12 carbon atoms, or an aralkyl group of 7 to 12 carbon atoms.
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