发明授权
US08759518B2 Intermediates for the preparation of HMG CoA reductase inhibitors and processes for the preparation thereof 失效
用于制备HMG CoA还原酶抑制剂的中间体及其制备方法

Intermediates for the preparation of HMG CoA reductase inhibitors and processes for the preparation thereof
摘要:
A compound of Formula (1), is disclosed wherein P1 and P2 are alcohol protecting groups or 1,3-diol protecting group, R is selected from: wherein R4a is selected from alkyl, aryl, arylalkyl and cycloalkyl, Rc is selected from H, alkyl, aryl, alkaoxy, haloalkyl, monohaloalkyloxy, and dihaloalkyloxy, Rd is selected from alkyl, aryl, arylalkyl, CF3, halo and NO2 and X is selected from O, N—H, N-alkyl and S, Ra and Rb are same or different and each represents hydrogen, an alkyl group of 1 to 12 carbon atoms, an aryl group of 6 to 12 carbon atoms, or an aralkyl group of 7 to 12 carbon atoms.
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