A method and apparatus for multiplexing frequency hopping in a wireless communication system using Orthogonal Frequency Division Multiple Access (OFDMA) is provided. The frequency hopping multiplexing method and apparatus efficiently indicates time division multiplexing for global hopping and local hopping by indicating and using the number and positions of slots for global hopping and local hopping to time-division-multiplex global hopping and local hopping in a reverse link, depending on information the number of Distributed Resource CHannels (DRCHs), provided from a transmitting side over a Forward link Secondary Broadcast Control CHannel (F-SBCCH), which is one of the forward common channels.