In some embodiments, the invention involves a framework for using virtualization technology to efficiently support a domain-specific run-time environment. In at least one embodiment, a framework is utilized to take advantage of virtualization technology (VT) to partition performance critical and non-performance critical tasks of the same domain-specific application. An embodiment of the invention utilizes a general-purpose operating system to execute non-performance critical aspects of a domain, and uses a privileged VT-root mode to execute performance critical aspects of the domain. Another embodiment uses one or more guest VMs to execute the performance critical aspects of the domain-specific run-time environment. Other embodiments are described and claimed.