发明授权
US08765820B2 Tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and/or LSD2
有权
作为组蛋白脱甲基酶LSD1和/或LSD2的抑制剂的苯丙氨酸衍生物
- 专利标题： Tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and/or LSD2
- 专利标题（中）： 作为组蛋白脱甲基酶LSD1和/或LSD2的抑制剂的苯丙氨酸衍生物
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申请号： US13641715申请日： 2011-04-15
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公开(公告)号： US08765820B2公开(公告)日： 2014-07-01
- 发明人: Saverio Minucci , Antonello Mai , Andrea Mattevi
- 申请人： Saverio Minucci , Antonello Mai , Andrea Mattevi
- 申请人地址： IT Rome IT Milan IT Pavia IT Milan
- 专利权人： Universita Degli Studi di Roma “La Sapienza”,Fondazione IEO,Universita Degli Studi di Pavia,Universita Degli Studi di Milano
- 当前专利权人： Universita Degli Studi di Roma “La Sapienza”,Fondazione IEO,Universita Degli Studi di Pavia,Universita Degli Studi di Milano
- 当前专利权人地址： IT Rome IT Milan IT Pavia IT Milan
- 代理机构： Lucas & Mercanti, LLP
- 国际申请： PCT/EP2011/055990 WO 20110415
- 国际公布： WO2011/131576 WO 20111027
- 主分类号： A61K31/015
- IPC分类号： A61K31/015 ; C07C329/00
摘要：
Tranylcypromine derivatives useful as therapeutic agents, particularly for the prevention and/or treatment of diseases and conditions associated with the activity of histone demethylases LSD1 and LSD2, such as the diseases characterized by deregulation of gene transcription, cell differentiation and proliferation, e.g. tumors, viral infections, are herein described. These compounds belong to the structural formula (I) wherein A and R3 are as defined in the specification. The invention also relates to the preparation of these compounds, as well as to compositions containing them and to therapeutic use thereof.
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