Invention Grant
US08772290B2 Alpha-arylmethoxyacrylate derivative, preparation method thereof, and pharmaceutical composition containing same
失效
α-芳基甲氧基丙烯酸酯衍生物，其制备方法和含有它们的药物组合物
- Patent Title: Alpha-arylmethoxyacrylate derivative, preparation method thereof, and pharmaceutical composition containing same
- Patent Title (中): α-芳基甲氧基丙烯酸酯衍生物，其制备方法和含有它们的药物组合物
-
Application No.: US13392024Application Date: 2011-04-21
-
Publication No.: US08772290B2Publication Date: 2014-07-08
- Inventor: Se-Won Kim , Jung Ho Kim , Se-Nyum Kim , Dae-Pil Kang , Youn Ho Han , Guo Fan Jin , Dong-Sik Jung , Sung-Ho Park , Ji Min Kim , Jhi Zheng
- Applicant: Se-Won Kim , Jung Ho Kim , Se-Nyum Kim , Dae-Pil Kang , Youn Ho Han , Guo Fan Jin , Dong-Sik Jung , Sung-Ho Park , Ji Min Kim , Jhi Zheng
- Applicant Address: KR Cheonan-si
- Assignee: Oscotech Inc.
- Current Assignee: Oscotech Inc.
- Current Assignee Address: KR Cheonan-si
- Agency: Sughrue Mion, PLLC
- Priority: KR10-2010-0037041 20100421
- International Application: PCT/KR2011/002892 WO 20110421
- International Announcement: WO2011/132967 WO 20111027
- Main IPC: A61K31/216
- IPC: A61K31/216 ; A61K31/336 ; A61K31/40 ; A61K31/415 ; A61K31/421 ; A61K31/4402 ; A61K31/4409 ; A61K31/4453 ; A61K31/5375
Abstract:
The present invention relates to an alpha-arylmethoxyacrylate derivative, a preparation method thereof and a pharmaceutical composition comprising the same, and the alpha-arylmethoxyacrylate derivative is inhibitory of HIF, which plays an important role in the regulation of genes associated with energy metabolism, vasomotion, angiogenesis and apoptosis and in the response of cells under hypoxic conditions, so that it can be used for preventing or treating of diseases such as cancer, arthritis, psoriasis, diabetic retinopathy and macular degeneration.
Public/Granted literature
Information query
