发明授权
US08778930B2 Process for the resolution of enantiomers of (3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)nitrile and application in the synthesis of ivabradine
有权
解决（3,4-二甲氧基 - 双环[4.2.0]八氢-1,3,5-三烯-7-基）腈的对映异构体的方法，并用于合成伊伐布雷定
![Process for the resolution of enantiomers of (3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)nitrile and application in the synthesis of ivabradine](/docs/US/2014-07-15/US08778930B2/abs.jpg.600x600.jpg)
- 专利标题： Process for the resolution of enantiomers of (3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)nitrile and application in the synthesis of ivabradine
- 专利标题（中）： 解决（3,4-二甲氧基 - 双环[4.2.0]八氢-1,3,5-三烯-7-基）腈的对映异构体的方法，并用于合成伊伐布雷定
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申请号： US13850514申请日： 2013-03-26
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公开(公告)号： US08778930B2公开(公告)日： 2014-07-15
- 发明人: Jean-Michel Lerestif , Jean-Pierre Lecouve , Daniel Dron , Eric Gojon , Maryse Phan
- 申请人： Les Laboratoires Servier
- 申请人地址： FR Suresnes Cedex
- 专利权人： Les Laboratories Servier
- 当前专利权人： Les Laboratories Servier
- 当前专利权人地址： FR Suresnes Cedex
- 代理机构： Hueschen and Sage
- 优先权： FR0804755 20080829
- 主分类号： A61K31/55
- IPC分类号： A61K31/55 ; C07D223/10 ; C07D223/16 ; C07C253/30 ; C07C255/47 ; C07C209/48
![Process for the resolution of enantiomers of (3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)nitrile and application in the synthesis of ivabradine](/abs-image/US/2014/07/15/US08778930B2/abs.jpg.150x150.jpg)
摘要：
Process for the optical resolution of the compound of formula (I): by chiral chromatography. Application in the synthesis of ivabradine, of its addition salts with a pharmaceutically acceptable acid and of their hydrates.
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