Patent search ap:("Les Laboratoires Servier") AND inv:"Eric Gojon" Page 1

1.

发明授权
Process for the resolution of enantiomers of (3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)nitrile and application in the synthesis of ivabradine 有权
Title translation: 解决（3,4-二甲氧基 - 双环[4.2.0]八氢-1,3,5-三烯-7-基）腈的对映异构体的方法，并用于合成伊伐布雷定

公开(公告)号：US08778930B2

公开(公告)日：2014-07-15

申请号：US13850514

申请日：2013-03-26

Applicant: Les Laboratoires Servier

Inventor： Jean-Michel Lerestif , Jean-Pierre Lecouve , Daniel Dron , Eric Gojon , Maryse Phan

IPC: A61K31/55 , C07D223/10 , C07D223/16 , C07C253/30 , C07C255/47 , C07C209/48

CPC classification number: C07C253/30 , C07C209/48 , C07C255/47 , C07D223/10 , C07D223/16

Abstract: Process for the optical resolution of the compound of formula (I): by chiral chromatography. Application in the synthesis of ivabradine, of its addition salts with a pharmaceutically acceptable acid and of their hydrates.

Abstract translation: 式（I）化合物的光学拆分方法：用手性色谱法。应用于伊伐布雷定的合成，其与药学上可接受的酸及其水合物的加成盐。

2.

发明授权
Process for the resolution of enantiomers of (3,4 dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)nitrile and application in the synthesis of ivabradine 有权
Title translation: （3,4-二甲氧基 - 双环[4.2.0]八氢-1,3,5-三烯-7-基）腈的对映异构体的拆分方法，适用于伊伐布雷定

公开(公告)号：US08927758B2

公开(公告)日：2015-01-06

申请号：US13850501

申请日：2013-03-26

Applicant: Les Laboratoires Servier

Inventor： Jean-Michel Lerestif , Jean-Pierre Lecouve , Daniel Dron , Eric Gojon , Maryse Phan

IPC: C07C255/00 , C07C211/00 , C07C253/30 , C07D223/16 , C07C209/48 , C07C255/47 , C07D223/10

CPC classification number: C07C253/30 , C07C209/48 , C07C255/47 , C07D223/10 , C07D223/16

Abstract: Process for the optical resolution of the compound of formula (I): by chiral chromatography. Application in the synthesis of ivabradine, of its addition salts with a pharmaceutically acceptable acid and of their hydrates.

Abstract translation: 式（I）化合物的光学拆分方法：用手性色谱法。应用于伊伐布雷定的合成，其与药学上可接受的酸及其水合物的加成盐。

3.

发明申请
NEW PROCESS FOR THE RESOLUTION OF ENANTIOMERS OF (3,4 DIMETHOXY-BICYCLO[4.2.0]OCTA-1,3,5-TRIEN-7-YL)NITRILE AND APPLICATION IN THE SYNTHESIS OF IVABRADINE 有权

公开(公告)号：US20130204032A1

公开(公告)日：2013-08-08

申请号：US13850501

申请日：2013-03-26

Applicant: Les Laboratoires Servier

Inventor： Jean-Michel LERESTIF , Jean-Pierre Lecouve , Daniel Dron , Eric Gojon , Maryse Phan

IPC: C07C255/47 , C07C209/48

CPC classification number: C07C253/30 , C07C209/48 , C07C255/47 , C07D223/10 , C07D223/16

Abstract: Process for the optical resolution of the compound of formula (I): by chiral chromatography.Application in the synthesis of ivabradine, of its addition salts with a pharmaceutically acceptable acid and of their hydrates.

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