Invention Grant
- Patent Title: Processes for preparing substituted pyrimidines
- Patent Title (中): 制备取代嘧啶的方法
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Application No.: US13585861Application Date: 2012-08-15
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Publication No.: US08779127B2Publication Date: 2014-07-15
- Inventor: Jean-Damien Charrier , Francesca Mazzei , David Kay , Andrew Miller
- Applicant: Jean-Damien Charrier , Francesca Mazzei , David Kay , Andrew Miller
- Applicant Address: US MA Boston
- Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee Address: US MA Boston
- Agent Rory C. Stewart
- Main IPC: C07D403/14
- IPC: C07D403/14 ; C07D403/12 ; C07D417/14
Abstract:
The present invention provides a facile process for the preparation of tri- and tetra—substituted pyrimidines. The process is useful for preparing inhibitors of protein kinases, especially Aurora kinase. These inhibitors are useful for treating or lessening the severity of Aurora—mediated diseases or conditions.
Public/Granted literature
- US20130066069A1 PROCESSES FOR PREPARING SUBSTITUTED PYRIMIDINES Public/Granted day:2013-03-14
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