Invention Grant
- Patent Title: Crystal of fused pyridine compound salt
- Patent Title (中): 稠合吡啶化合物的晶体
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Application No.: US13806909Application Date: 2011-06-22
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Publication No.: US08779140B2Publication Date: 2014-07-15
- Inventor: Takashi Kikuchi , Katsuhiko Gato , Koichiro Mukoyoshi , Tsuyoshi Kitamura , Takeshi Kawakami , Hironobu Yasuda
- Applicant: Takashi Kikuchi , Katsuhiko Gato , Koichiro Mukoyoshi , Tsuyoshi Kitamura , Takeshi Kawakami , Hironobu Yasuda
- Applicant Address: JP Tokyo
- Assignee: Astellas Pharma Inc.
- Current Assignee: Astellas Pharma Inc.
- Current Assignee Address: JP Tokyo
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2010-143226 20100623
- International Application: PCT/JP2011/064291 WO 20110622
- International Announcement: WO2011/162300 WO 20111229
- Main IPC: C07D471/04
- IPC: C07D471/04

Abstract:
[Problem]A salt or crystal of a compound which is highly stable in a solid state and useful as a bulk material for the preparation of a pharmaceutical product is provided.[Means for Solution]4-{[(1R,2s,3S,5s,7s)-5-Hydroxy-2-adamantyl]amino}-1H-pyrrolo[2,3-b]pyridine-5-carboxamide succinate, 4-{[(1R,2s,3S,5s,7s)-5-hydroxy-2-adamantyl]amino}-1H-pyrrolo[2,3-b]pyridine-5-carboxamide hydrobromide, and 4-{[(1R,2s,3S,5s,7s)-5-hydroxy-2-adamantyl]amino}-1H-pyrrolo[2,3-b]pyridine-5-carboxamide hydrochloride and crystals thereof are useful as a bulk material for the preparation of a solid preparation, in particular, a solid dispersion preparation. Furthermore, the crystal of the hydrobromide has excellent stability in a solid state and is useful as a bulk material for the preparation of a pharmaceutical product.
Public/Granted literature
- US20130102628A1 CRYSTAL OF FUSED PYRIDINE COMPOUND SALT Public/Granted day:2013-04-25
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