An approach is provided in which a local module receives a data frame initiated by a first virtual machine and has a target destination at a second virtual machine, which executes on a destination host system. The local module identifies a destination local port ID and a destination global queue pair number corresponding to the second virtual machine. In one embodiment, the destination local port ID corresponds to the destination host, but the destination global queue pair number is independent of the destination host. The local module includes the destination global queue pair number and the destination local port ID in an overlay header and encapsulates the data frame with the overlay header, which results in an encapsulated frame. In turn, the local module sends the encapsulated frame through a computer network to the second virtual machine.