发明授权
- 专利标题： Substituted pyrrolo-pyrazole derivatives as kinase inhibitors
- 专利标题（中）： 取代的吡咯并吡唑衍生物作为激酶抑制剂
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申请号： US14010819申请日： 2013-08-27
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公开(公告)号： US08785448B2公开(公告)日： 2014-07-22
- 发明人: Maria Gabriella Brasca , Raffaella Amici , Daniele Fancelli , Marcella Nesi , Paolo Orsini , Fabrizio Orzi , Patrick Roussel , Anna Vulpetti , Paolo Pevarello
- 申请人： Maria Gabriella Brasca , Raffaella Amici , Daniele Fancelli , Marcella Nesi , Paolo Orsini , Fabrizio Orzi , Patrick Roussel , Anna Vulpetti , Paolo Pevarello
- 申请人地址： IT Nerviano (MI)
- 专利权人： Nerviano Medical Sciences S.R.L.
- 当前专利权人： Nerviano Medical Sciences S.R.L.
- 当前专利权人地址： IT Nerviano (MI)
- 代理机构： Scully, Scott, Murphy & Presser, P.C.
- 主分类号： A61K31/496
- IPC分类号： A61K31/496 ; C07D403/14
摘要：
Compounds represented by formula (Ia) or (Ib) and wherein R and R1 are as defined in the description, and pharmaceutically acceptable salts thereof, are disclosed; the said compounds are useful in the treatment of cell cycle proliferative disorders, e.g. cancer, associated with an altered cell cycle dependent kinase activity.