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Invention Grant
US08785503B2 Biphenyl compound or pharmaceutically acceptable salt thereof, method for preparing novel biphenyl compound or pharmaceutically acceptable salt thereof, and pharmaceutical composition containing same as active ingredient for preventing or treating diabetes complications 有权
联苯化合物或其药学上可接受的盐，制备新型联苯化合物或其药学上可接受的盐的方法和含有其作为预防或治疗糖尿病并发症的活性成分的药物组合物

Biphenyl compound or pharmaceutically acceptable salt thereof, method for preparing novel biphenyl compound or pharmaceutically acceptable salt thereof, and pharmaceutical composition containing same as active ingredient for preventing or treating diabetes complications
Abstract:
The present invention provides a novel biphenyl compound or pharmaceutically acceptable salts thereof, methods for preparing the same, and pharmaceutical compositions for preventing or treating diabetic complications containing the same as an active ingredient. Novel biphenyl compounds, according to the present invention, effectively suppress generation activity of advanced glycation end products, which cause diabetic complications and are a criterion for evaluating the effectiveness of a treating agent for diabetic complications, and show an excellent therapeutic effect on retina blood vessels, increased occludin, and decreased angiogenic growth factor in actual diabetic retinopathy induced retina. Thus, novel biphenyl compounds according to the present invention can be used effectively as an active ingredient in compositions for preventing or treating diabetic complications such as diabetic retinopathy.
Abstract(Chinese):

本发明提供了一种新的联苯化合物或其药学上可接受的盐，其制备方法，以及用于预防或治疗含有其作为活性成分的糖尿病并发症的药物组合物。 根据本发明的新型联苯化合物有效地抑制了引起糖尿病并发症的晚期糖基化终产物的产生活性，并且是评价治疗剂对糖尿病并发症的有效性的标准，对视网膜血管显示出优异的治疗效果 ，增加闭合蛋白，并减少血管生成生长因子在实际糖尿病视网膜病变诱导的视网膜。 因此，根据本发明的新型联苯化合物可以有效地用作用于预防或治疗糖尿病性视网膜病变的糖尿病并发症的组合物中的活性成分。

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