发明授权
US08791255B2 (6-oxo-1,6-dihydropyrimidin-2-yl)amide derivatives, preparation thereof and pharmaceutical use thereof as AKT(PKB) phosphorylation inhibitors
有权
(6-氧代-1,6-二氢嘧啶-2-基)酰胺衍生物,其制备方法及其作为AKT(PKB)磷酸化抑制剂的药物用途
- 专利标题: (6-oxo-1,6-dihydropyrimidin-2-yl)amide derivatives, preparation thereof and pharmaceutical use thereof as AKT(PKB) phosphorylation inhibitors
- 专利标题(中): (6-氧代-1,6-二氢嘧啶-2-基)酰胺衍生物,其制备方法及其作为AKT(PKB)磷酸化抑制剂的药物用途
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申请号: US13338011申请日: 2011-12-27
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公开(公告)号: US08791255B2公开(公告)日: 2014-07-29
- 发明人: Jean-Christophe Carry , Victor Certal , Frank Halley , Karl Andreas Karlsson , Laurent Schio , Fabienne Thompson
- 申请人: Jean-Christophe Carry , Victor Certal , Frank Halley , Karl Andreas Karlsson , Laurent Schio , Fabienne Thompson
- 申请人地址: FR Paris
- 专利权人: Sanofi
- 当前专利权人: Sanofi
- 当前专利权人地址: FR Paris
- 代理商 Brian R. Morrill
- 优先权: FR0903239 20090702; FR0957070 20091009
- 主分类号: C07D413/04
- IPC分类号: C07D413/04
摘要:
The invention relates to the novel materials of formula (I), wherein each of the substituents R, R1, R2, R3, R4 and R5 is as defined herein. The materials are useful as inhibitors of AKT(PKB) phosphorylation.