Invention Grant
US08791255B2 (6-oxo-1,6-dihydropyrimidin-2-yl)amide derivatives, preparation thereof and pharmaceutical use thereof as AKT(PKB) phosphorylation inhibitors
有权
（6-氧代-1,6-二氢嘧啶-2-基）酰胺衍生物，其制备方法及其作为AKT（PKB）磷酸化抑制剂的药物用途
- Patent Title: (6-oxo-1,6-dihydropyrimidin-2-yl)amide derivatives, preparation thereof and pharmaceutical use thereof as AKT(PKB) phosphorylation inhibitors
- Patent Title (中): （6-氧代-1,6-二氢嘧啶-2-基）酰胺衍生物，其制备方法及其作为AKT（PKB）磷酸化抑制剂的药物用途
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Application No.: US13338011Application Date: 2011-12-27
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Publication No.: US08791255B2Publication Date: 2014-07-29
- Inventor: Jean-Christophe Carry , Victor Certal , Frank Halley , Karl Andreas Karlsson , Laurent Schio , Fabienne Thompson
- Applicant: Jean-Christophe Carry , Victor Certal , Frank Halley , Karl Andreas Karlsson , Laurent Schio , Fabienne Thompson
- Applicant Address: FR Paris
- Assignee: Sanofi
- Current Assignee: Sanofi
- Current Assignee Address: FR Paris
- Agent Brian R. Morrill
- Priority: FR0903239 20090702; FR0957070 20091009
- Main IPC: C07D413/04
- IPC: C07D413/04
Abstract:
The invention relates to the novel materials of formula (I), wherein each of the substituents R, R1, R2, R3, R4 and R5 is as defined herein. The materials are useful as inhibitors of AKT(PKB) phosphorylation.
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