A microprocessor includes a model specific register (MSR) having an address, fuses manufactured with a first predetermined value, and a control register. The microprocessor initially loads the first predetermined value from fuses into the control register. The microprocessor also receives a second predetermined value into the control register from system software of a computer system comprising the microprocessor subsequent to initially loading the first predetermined value into the control register. The microprocessor prohibits access to the MSR by an instruction that provides a first password generated by encrypting a function of the first predetermined value and the MSR address with a secret key manufactured into the first instance of the microprocessor and enables access to the MSR by an instruction that provides a second password generated by encrypting the function of the second predetermined value and the MSR address with the secret key.