发明授权
US08796295B2 Substituted benzamide analogs as mGluR5 negative allosteric modulators and methods of making and using the same
有权
取代的苯甲酰胺类似物作为mGluR5负变构调节剂及其制备和使用方法
- 专利标题： Substituted benzamide analogs as mGluR5 negative allosteric modulators and methods of making and using the same
- 专利标题（中）： 取代的苯甲酰胺类似物作为mGluR5负变构调节剂及其制备和使用方法
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申请号： US12885378申请日： 2010-09-17
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公开(公告)号： US08796295B2公开(公告)日： 2014-08-05
- 发明人: P. Jeffrey Conn , Craig W. Lindsley , Kyle A. Emmitte , Charles David Weaver , Alice L. Rodriguez , Andrew S. Felts , Carrie K. Jones , Brittney S. Bates
- 申请人： P. Jeffrey Conn , Craig W. Lindsley , Kyle A. Emmitte , Charles David Weaver , Alice L. Rodriguez , Andrew S. Felts , Carrie K. Jones , Brittney S. Bates
- 申请人地址： US TN Nashville
- 专利权人： Vanderbilt University
- 当前专利权人： Vanderbilt University
- 当前专利权人地址： US TN Nashville
- 代理机构： Ballard Spahr LLP
- 主分类号： A61K31/505
- IPC分类号： A61K31/505 ; A61K31/44 ; C07D239/02 ; C07D417/12
摘要：
Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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