发明授权
- 专利标题： Stabilized alpha helical peptides and uses thereof
- 专利标题（中）： 稳定的α螺旋肽及其用途
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申请号： US12233555申请日： 2008-09-18
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公开(公告)号： US08796418B2公开(公告)日： 2014-08-05
- 发明人: Loren D. Walensky , Stanley J. Korsmeyer , Gregory L. Verdine
- 申请人： Loren D. Walensky , Gregory L. Verdine , Susan Korsmeyer
- 申请人地址： US MA Boston US MA Cambridge
- 专利权人： Dana-Farber Cancer Institute, Inc.,President and Fellows of Harvard College
- 当前专利权人： Dana-Farber Cancer Institute, Inc.,President and Fellows of Harvard College
- 当前专利权人地址： US MA Boston US MA Cambridge
- 代理机构： Wilson Sonsini Goodrich & Rosati, P.C.
- 主分类号： C07K1/00
- IPC分类号： C07K1/00
摘要：
Novel polypeptides and methods of making and using the same are described herein. The polypeptides include cross-linking (“hydrocarbon stapling”) moieties to provide a tether between two amino acid moieties, which constrains the secondary structure of the polypeptide. The polypeptides described herein can be used to treat diseases characterized by excessive or inadequate cellular death.
公开/授权文献
- US20090149630A1 Stabilized Alpha Helical Peptides and Uses Thereof 公开/授权日：2009-06-11
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