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54 条记录 (耗时 0.03 秒)

    Preparation of romidepsin
    6.
    发明授权
    Preparation of romidepsin 有权
    罗非曲汀的制备

    公开(公告)号：US08691534B2

    公开(公告)日：2014-04-08

    申请号：US11966258

    申请日：2007-12-28

    申请人： Gregory L. Verdine ,  Nicholas H. Vrolijk ,  Stephan Bertel

    发明人： Gregory L. Verdine ,  Nicholas H. Vrolijk ,  Stephan Bertel

    IPC分类号： C12P21/04

    CPC分类号： C07K5/101

    摘要： The invention provides an improved process for preparing romidepsin. The process involves producing, purifying, or storing romidepsin under conditions that prevent the formation of undesired adducts. Purifying romidepsin at an apparent pH lower than approximately 6.0 (e.g., between an apparent pH of 4.0 and 6.0) has been discovered to prevent the reduction of the disulfide bond of romidepsin and the subsequent formation of dimerized, oligomerized, or polymerized adducts. The invention also provides compositions of monomeric romidepsin free of dimerized, oligomerized, or polymerized adducts.

    摘要翻译： 本发明提供了一种制备罗美甜素的改进方法。 该方法包括在防止形成不需要的加合物的条件下生产，纯化或存储罗非曲松。 已经发现在表观pH低于约6.0（例如，表观pH为4.0和6.0之间）的情况下纯化罗非曲松，以防止罗非替辛的二硫键的还原和随后形成二聚，低聚或聚合的加合物。 本发明还提供了不含二聚，低聚或聚合的加合物的单体罗非替克组合物。

    PREPARATION OF ROMIDEPSIN
    8.
    发明申请
    PREPARATION OF ROMIDEPSIN 审中-公开
    ROMIDEPSIN的制备

    公开(公告)号：US20090209616A1

    公开(公告)日：2009-08-20

    申请号：US12420451

    申请日：2009-04-08

    申请人： Gregory L. Verdine ,  Nicholas H. Vrolijk ,  Stephan Bertel

    发明人： Gregory L. Verdine ,  Nicholas H. Vrolijk ,  Stephan Bertel

    IPC分类号： A61K31/39 ,  A61P43/00

    CPC分类号： C07K5/101

    摘要： The invention provides an improved process for preparing romidepsin. The process involves producing, purifying, or storing romidepsin under conditions that prevent the formation of undesired adducts. Purifying romidepsin at an apparent pH lower than approximately 6.0 (e.g., between an apparent pH of 4.0 and 6.0) has been discovered to prevent the reduction of the disulfide bond of romidepsin and the subsequent formation of dimerized, oligomerized, or polymerized adducts. The invention also provides compositions of monomeric romidepsin free of dimerized, oligomerized, or polymerized adducts.

    摘要翻译： 本发明提供了一种制备罗美甜素的改进方法。 该方法包括在防止形成不需要的加合物的条件下生产，纯化或存储罗非曲松。 已经发现在表观pH低于约6.0（例如，表观pH为4.0和6.0之间）的情况下净化罗非曲松，以防止罗非替辛的二硫键的还原和随后形成二聚，低聚或聚合的加合物。 本发明还提供了不含二聚，低聚或聚合的加合物的单体罗非替克组合物。

    Uridine analogs and techniques for making and using
    9.
    发明授权
    Uridine analogs and techniques for making and using 有权

    公开(公告)号：US06987180B2

    公开(公告)日：2006-01-17

    申请号：US10072641

    申请日：2002-02-07

    申请人： Gregory L. Verdine ,  Michael Storek

    发明人： Gregory L. Verdine ,  Michael Storek

    IPC分类号： C07H19/06 ,  C07H19/067 ,  C07H19/09

    CPC分类号： A61K51/0491 ,  C07H19/06 ,  C07H19/10 ,  C07H21/00

    摘要： Uridine analogs and techniques for making and using uridine analogs are disclosed in this invention. These uridine analogs include nucleoside phosphates having a 5-aminouracil group. These nucleotides can be incorporated into a nucleic acid as an unnatural base, as a substitute for uridine or thymine. The nucleic acid can then be treated with an oxidizing agent and an alkaline solution, which causes cleavage of the nucleic acid at the position of the unnatural base. The nucleoside phosphate analogs can be used in many ways, including measuring chemical interactions between nucleic acids and other compounds, or sequencing nucleic acids. Additional compounds can also be derivitized onto the amino group, allowing other functionalities to be added to the nucleoside phosphate, or to the nucleic acid incorporating the nucleoside phosphate.

    Template-directed interference footprinting of protein-adenine contacts
    10.
    发明授权
    Template-directed interference footprinting of protein-adenine contacts 有权
    模板导向的蛋白质 - 腺嘌呤接触的干扰足迹

    公开(公告)号：US06312897B1

    公开(公告)日：2001-11-06

    申请号：US09214207

    申请日：1999-11-04

    申请人： Gregory L. Verdine ,  Timothy D. Cushing

    发明人： Gregory L. Verdine ,  Timothy D. Cushing

    IPC分类号： C12Q168

    CPC分类号： C07H21/00 ,  C07H19/14 ,  C12Q2525/101

    摘要： A chemical analog of adenine is provided which can be incorporated into DNA but base pairs as normal, and does not disrupt DNA secondary structure. The analog is cleavable and disrupts functionality with DNA-binding protein. The analog finds use in a technique provided by the invention involving TDI footprinting or adenine-DNA contacts.

    摘要翻译： 提供腺嘌呤的化学类似物，其可以正常并入DNA但碱基对，并且不破坏DNA二级结构。 该类似物可裂解并破坏DNA结合蛋白的功能。 该类似物用于本发明提供的涉及TDI足迹或腺嘌呤-DNA接触的技术中。