A process for partial oxidation of hydrocarbons in a reactor, in which a stream comprising the hydrocarbon and a stream comprising the oxygen are fed to the reactor, wherein both streams fed to the reactor are conducted within the reactor separately through in each case one or more spatially separate lines, these lines having turbulence generators in their interior, owing to which, as a result of the imposed deflection of the flow direction downstream of turbulence generators, a highly turbulent flow field forms, and the streams are then mixed in a mixing zone after exiting from the lines and then converted in a reaction zone.