Invention Grant
- Patent Title: Patch and method for producing the same
- Patent Title (中): 补片及其制作方法
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Application No.: US13772843Application Date: 2013-02-21
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Publication No.: US08802134B2Publication Date: 2014-08-12
- Inventor: Naruhito Higo , Tetsurou Tateishi , Takaaki Terahara , Kazunosuke Aida , Shigeki Hayashi , Nobuo Tsutsumi
- Applicant: Hisamitsu Pharmaceutical Co., Inc.
- Applicant Address: JP Tosu-shi
- Assignee: Hisamitsu Pharmaceutical Co., Inc.
- Current Assignee: Hisamitsu Pharmaceutical Co., Inc.
- Current Assignee Address: JP Tosu-shi
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2012-267026 20121206
- Main IPC: A61K9/00
- IPC: A61K9/00 ; A61F13/02

Abstract:
A method for producing a patch having a high skin penetrability and a high pharmaceutical physical properties such as adhesion and cohesiveness, and a long-term storability. The patch is produced by first obtaining an adhesive agent layer composition containing oxybutynin and/or salt thereof as a drug, an acrylic-based polymer and/or a rubber-based polymer as an adhesive base agent, liquid paraffin, an organic acid, and a tackifier; heating the adhesive agent layer composition at a temperature in a range from a melting point of the drug to a temperature higher than the melting point by 10° C. for 2 to 24 hours; and slowly cooling the heated adhesive agent layer composition to obtain the adhesive agent layer comprising the drug at a supersaturated concentration in a dissolved form.
Public/Granted literature
- US20140161865A1 PATCH AND METHOD FOR PRODUCING THE SAME Public/Granted day:2014-06-12
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