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公开(公告)号：USD1000951S1
公开(公告)日：2023-10-10
申请号：US29826061
申请日：2022-02-09
设计人： Sayaka Mochizuki , Shigeo Kusumi
摘要： The patent or application file contains at least one drawing executed in color. Copies of this patent or patent application publication with color drawing(s) will be provided by the Office upon request and payment of the necessary fee.
FIG. 1 is a front view of a packing box of the present invention;
FIG. 2 is a rear view thereof;
FIG. 3 is a top plan view thereof;
FIG. 4 is a bottom plan view thereof;
FIG. 5 is a right side view thereof;
FIG. 6 is a left side view thereof;
FIG. 7 is a front perspective view thereof; and,
FIG. 8 is a rear perspective view thereof.
The broken lines in the drawings are shown for the purpose of illustrating parts of the article that form no part of the claimed design.
Salonpas® is a registered trademark from Hisamitsu Pharmaceutical Co., Inc. forming part of the claimed design.-
公开(公告)号：USD985232S1
公开(公告)日：2023-05-09
申请号：US29740921
申请日：2020-07-08
设计人： Akinori Sanada
摘要： FIG. 1 is a front perspective view of a character costume showing the new design;
FIG. 2 is a rear perspective view thereof;
FIG. 3 is a front view thereof,
FIG. 4 is a rear view thereof;
FIG. 5 is atop plan view thereof;
FIG. 6 is a bottom view thereof;
FIG. 7 is a right side view thereof; and,
FIG. 8 is a left side view thereof.
The broken lines in the figures show portions of the character costume that form no part of the claimed design.-
公开(公告)号：US11590106B2
公开(公告)日：2023-02-28
申请号：US17281623
申请日：2019-09-25
发明人： Masaki Yukuhiro , Yuka Takagi , Yasunari Michinaka
IPC分类号： A61K31/407 , A61K9/70 , A61K47/02 , A61K47/12 , A61K47/32
摘要： An object of the present invention is to provide an asenapine-containing patch having excellent sustained-release properties while enhancing skin permeability by using a silicone-based pressure-sensitive adhesive base. The present invention relates to a patch having a support and a pressure-sensitive adhesive layer, wherein the pressure-sensitive adhesive layer comprises asenapine and/or a pharmaceutically acceptable salt thereof, a silicone-based pressure-sensitive adhesive base and a release control agent, and the ratio of the maximum skin permeation rate of asenapine to the minimum skin permeation rate from the time when the maximum skin permeation rate is reached to 24 hours is less than 1.62.
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公开(公告)号：US20230034383A1
公开(公告)日：2023-02-02
申请号：US17381294
申请日：2021-07-21
发明人： Yuka TAKAGI , Kazuya ISHIDA , Ryoma TAMURA , Takao KUROKAWA , Yasunari MICHINAKA
IPC分类号： A61K31/407 , A61K9/70 , A61K47/06
摘要： A method for reducing skin sensitization of an asenapine-containing patch comprising a backing layer and an adhesive agent layer, the method comprising: using an adhesive agent for preparing the adhesive agent layer, the adhesive agent containing free asenapine in a range of 2 to 5% by mass, styrene-isoprene-styrene block copolymer (SIS) in a range of 7 to 18% by mass, polyisobutylene (PIB) in a range of 0.5 to 10% by mass, alicyclic saturated hydrocarbon resin in a range of 30 to 70% by mass, and liquid paraffin in a range of 5 to 10% by mass, relative to a total amount of the adhesive agent; and preparing the asenapine-containing patch whose average cumulative amount of skin permeation of asenapine (24 hours) after applying the asenapine-containing patch to skin of a dorsal scapular region of a 5-week-old Hartley white female guinea pig and holding the asenapine-containing patch with an occlusive dressing for 24 hours is in a range of 90 to 300 μg/cm2 in terms of free form.
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公开(公告)号：US11464956B2
公开(公告)日：2022-10-11
申请号：US16488456
申请日：2018-02-20
摘要： A microneedle device of the present invention comprises a substrate, microneedles disposed on the substrate, and a coating layer formed on the microneedles, wherein a length of the microneedles is 300 to 500 μm, the microneedles are disposed on the substrate at a density of 28 to 80 needles/cm2, and the coating layer comprises a biologically active substance. The microneedle device allows the skin irritation caused by administration of an agent to be reduced.
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公开(公告)号：US20220125626A1
公开(公告)日：2022-04-28
申请号：US17430035
申请日：2020-02-14
IPC分类号： A61F7/02 , C09J129/04 , C08K5/12
摘要： A cooling sheet comprising: a backing layer; an adhesive agent layer; and a liner layer for protecting the adhesive agent layer, wherein the adhesive agent layer contains water at 65 to 85% by mass based on a total mass of the adhesive agent layer, polyalkylene glycol monooleate at 0.12 to 0.7% by mass based on the total mass of the adhesive agent layer, polyvinyl alcohol at 3 to 10% by mass based on the total mass of the adhesive agent layer, polyacrylic acid at 0.5 to 5% by mass based on the total mass of the adhesive agent layer, and a parahydroxybenzoate at 0.01 to 1% by mass based on the total mass of the adhesive agent layer, and a mass ratio of a content of the polyvinyl alcohol to a content of the polyacrylic acid is in a range of 1.2:1 to 5:1.
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公开(公告)号：US11219601B2
公开(公告)日：2022-01-11
申请号：US16975161
申请日：2019-02-19
摘要： The present invention provides an emulsified gel composition comprising a physiologically active substance, water, a gelling agent, an anti-peeling agent, and a surfactant having an HLB value of 18 to 20, in which the gelling agent is a nonionic water-soluble polymer, and the anti-peeling agent is one or more compounds selected from the group consisting of sucrose, sorbitol, polyethylene glycol, glycerin, a (meth)acrylic-based polymer compound, and a polyoxyethylene hydrogenated castor oil.
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公开(公告)号：US20210393587A1
公开(公告)日：2021-12-23
申请号：US17281623
申请日：2019-09-25
发明人： Masaki Yukuhiro , Yuka Takagi , Yasunari Michinaka
IPC分类号： A61K31/407 , A61K9/70 , A61K47/02 , A61K47/32 , A61K47/12
摘要： An object of the present invention is to provide an asenapine-containing patch having excellent sustained-release properties while enhancing skin permeability by using a silicone-based pressure-sensitive adhesive base. The present invention relates to a patch having a support and a pressure-sensitive adhesive layer, wherein the pressure-sensitive adhesive layer comprises asenapine and/or a pharmaceutically acceptable salt thereof, a silicone-based pressure-sensitive adhesive base and a release control agent, and the ratio of the maximum skin permeation rate of asenapine to the minimum skin permeation rate from the time when the maximum skin permeation rate is reached to 24 hours is less than 1.62.
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公开(公告)号：US11166921B2
公开(公告)日：2021-11-09
申请号：US16963537
申请日：2019-01-23
IPC分类号： A61K9/70 , A61K31/045 , A61K31/05 , A61K31/125 , A61K31/618 , A61K36/534
摘要： The present invention provides a patch comprising a backing layer and an adhesive agent layer, wherein the adhesive agent layer is non-aqueous, the adhesive agent layer contains nonylic acid vanillylamide, terpene-based resin, rosin-based resin, styrene-isoprene-styrene block copolymer, and liquid paraffin, a mass ratio of a content of the terpene-based resin to a content of the rosin-based resin ((content of the terpene-based resin)/(content of the rosin-based resin)) in the adhesive agent layer is 0.45 to 1.3, and a mass ratio of a content of the styrene-isoprene-styrene block copolymer to a content of the liquid paraffin ((content of the styrene-isoprene-styrene block copolymer)/(content of the liquid paraffin)) in the adhesive agent layer is 0.45 to 1.2.
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公开(公告)号：US11141576B2
公开(公告)日：2021-10-12
申请号：US16471290
申请日：2017-12-15
发明人： Takuya Tajima , Naoki Yamamoto , Seiji Tokumoto
IPC分类号： A61M37/00
摘要： An applicator of one embodiment is for applying a sheet member to skin. The applicator includes: a body including a bottom plate configured to face the skin and a bending portion provided to the bottom plate; a cap being movable along a slide direction substantially orthogonal to the bottom plate; and an elastic member configured to extend along the slide direction between the body and the cap. The elastic member applies, to the cap, elastic force that acts in a direction away from the bottom plate, the cap being movable toward the bottom plate against the elastic force. The bending portion bends the sheet member that has advanced thereto in a pressed state in which the cap has been moved toward the bottom plate, thereby applying the sheet member to the skin.
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