发明授权
- 专利标题： Acylamino-substituted fused cyclopentanecarboxylic acid derivatives and their use as pharmaceuticals
- 专利标题（中）： 酰氨基取代的稠环戊烷羧酸衍生物及其作为药物的用途
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申请号： US13867293申请日： 2013-04-22
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公开(公告)号： US08802720B2公开(公告)日： 2014-08-12
- 发明人: Matthias Schaefer , Josef Pernerstorfer , Dieter Kadereit , Hartmut Strobel , Werngard Czechtizky , L. Charlie Chen , Alena Safarova , Aleksandra Weichsel , Marcel Patek
- 申请人： SANOFI
- 申请人地址： FR Paris
- 专利权人： Sanofi
- 当前专利权人： Sanofi
- 当前专利权人地址： FR Paris
- 代理商 Jiang Lin
- 优先权： EP08290427 20080505
- 主分类号： A61K31/381
- IPC分类号： A61K31/381 ; A61K31/44 ; C07D333/38 ; C07D213/82
摘要：
The present invention relates to compounds of the formula I, wherein A, Y, Z, R3 to R6, R20 to R22 and R50 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they are inhibitors of the endothelial differentiation gene receptor 2 (Edg-2, EDG2), which is activated by lysophosphatidic acid (LPA) and is also termed as LPA1 receptor, and are useful for the treatment of diseases such as atherosclerosis, myocardial infarction and heart failure, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.
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