A protective circuit compares at least two different signals and asserts a control node toward respective logic states accordingly. At least one of the signals is derived from a voltage on a power rail within a computer or other device. A switching element passes or isolates an enable signal based on the logic state of the control node, enabling or preventing operation of a power supply, accordingly. Central processing units (CPUs) or other elements are protected against electrically caused damage in the event that a fault is detected by the protective circuit.