An exhaust purification system is provided that can continuously maintain a NOx purification rate to be high while suppressing the occurrence of ammonia slip. The exhaust purification system includes a slip determination portion 34 that determines the occurrence of ammonia slip based on an output value NH3CONS of an ammonia sensor 26. A reference injection amount calculating portion 31 calculates a reference injection amount GUREA—BS based on a parameter correlating to an operating state of an engine. A switching injection amount calculating portion 32 decreases in amount a urea injection amount GUREA by setting a switching injection amount GUREA—SW to a negative value in response to having determined that ammonia slip has occurred, and increases in amount the injection amount GUREA by setting the switching injection amount GUREA—SW to a positive value in response to a storage amount estimated value STUREA having fallen below a predetermined switch storage amount STUREA—SW.