发明授权
US08815566B2 High eicosapentaenoic acid producing strains of Yarrowia lipolytica
有权
高二十碳五烯酸生产的解脂耶氏酵母菌株
- 专利标题： High eicosapentaenoic acid producing strains of Yarrowia lipolytica
- 专利标题（中）： 高二十碳五烯酸生产的解脂耶氏酵母菌株
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申请号： US13943992申请日： 2013-07-17
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公开(公告)号： US08815566B2公开(公告)日： 2014-08-26
- 发明人: Howard Glenn Damude , Peter John Gillies , Daniel Joseph Macool , Stephen K Picataggio , Dana M. Walters Pollak , James John Ragghianti , Zhixiong Xue , Narendra S Yadav , Hongxiang Zhang , Quinn Qun Zhu
- 申请人： E I du Pont de Nemours and Company
- 申请人地址： US DE Wilmington
- 专利权人： E I du Pont de Nemours and Company
- 当前专利权人： E I du Pont de Nemours and Company
- 当前专利权人地址： US DE Wilmington
- 主分类号： C12N1/00
- IPC分类号： C12N1/00 ; C12P7/64 ; C12N9/12 ; C07H21/04
摘要：
Engineered strains of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 25% eicosapentaenoic acid (EPA, an ω-3 polyunsaturated fatty acid) in the total oil fraction are described. These strains comprise various chimeric genes expressing heterologous desaturases, elongases and acyltransferases and optionally comprise various native desaturase and acyltransferase knockouts to enable synthesis and high accumulation of EPA. Production host cells are claimed, as are methods for producing EPA within said host cells.
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