发明授权
US08815794B2 Treatment of amyloidoses using myelin basic protein and fragments thereof
有权
使用髓磷脂碱性蛋白及其片段治疗淀粉样变性
- 专利标题: Treatment of amyloidoses using myelin basic protein and fragments thereof
- 专利标题(中): 使用髓磷脂碱性蛋白及其片段治疗淀粉样变性
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申请号: US13061433申请日: 2009-08-28
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公开(公告)号: US08815794B2公开(公告)日: 2014-08-26
- 发明人: William E. Van Nostrand
- 申请人: William E. Van Nostrand
- 申请人地址: US NY Albany
- 专利权人: The Research Foundation for the State University of New York
- 当前专利权人: The Research Foundation for the State University of New York
- 当前专利权人地址: US NY Albany
- 代理机构: Medlen & Carroll, LLP
- 国际申请: PCT/US2009/004907 WO 20090828
- 国际公布: WO2010/024927 WO 20100304
- 主分类号: A61K38/10
- IPC分类号: A61K38/10
摘要:
In its various embodiments, the invention provides myelin basic proteins and fragments of that interfere with the fibril lization of peptides implicated in the amyloidoses, especially the amyloid-beta peptide associated with Alzheimer's disease (“AD”) and cerebral amyloid angiopathy (“CAA”). Some embodiments provide methods of identifying additional interfering fragments. Others provide methods of identifying substances that modulate the interference. Further embodiments provide methods of preventing amyloidoses, especially AD and CAA by administering myelin basic proteins or fragments thereof.