发明授权
- 专利标题： Tumor activated prodrugs
- 专利标题（中）： 肿瘤活化前药
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申请号： US13484795申请日： 2012-05-31
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公开(公告)号： US08822406B2公开(公告)日： 2014-09-02
- 发明人: Samuel R. Denmeade , John T. Isaacs
- 申请人： Samuel R. Denmeade , John T. Isaacs
- 申请人地址： US TX San Antonio
- 专利权人： GenSpera, Inc.
- 当前专利权人： GenSpera, Inc.
- 当前专利权人地址： US TX San Antonio
- 代理机构： Logue, P.C.
- 主分类号： A61K38/08
- IPC分类号： A61K38/08 ; C07K7/06 ; A61K47/48 ; A61K38/16
摘要：
The instant invention provides compositions comprising a prodrug, the prodrug comprising a therapeutically active drug; and a peptide selected from the group consisting of the sequences: Ser-Ser-Lys-Tyr-Gln (SEQ ID NO:1); Gly-Lys-Ser-Gln-Tyr-Gln (SEQ ID NO:2); and Gly-Ser-Ala-Lys-Tyr-Gln (SEQ ID NO:3) wherein the peptide is linked to the therapeutically active drug to inhibit the therapeutic activity of the drug, and wherein the therapeutically active drug is cleaved from the peptide upon proteolysis by an enzyme having a proteolytic activity of prostate specific antigen (PSA). The invention further provides methods of making and using the claimed compositions.
公开/授权文献
- US20120270767A1 Tumor Activated Prodrugs 公开/授权日：2012-10-25
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