发明授权
- 专利标题： PIM kinase inhibitors and methods of their use
- 专利标题（中）： PIM激酶抑制剂及其使用方法
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申请号： US12449701申请日： 2008-03-03
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公开(公告)号： US08822497B2公开(公告)日： 2014-09-02
- 发明人: Matthew Burger , Mika Lindvall , Wooseok Han , Jiong Lan , Gisele Nishiguchi , Cynthia Shafer , Cornelia Bellamacina , Kay Huh , Gordana Atallah , Christopher McBride , William Antonios-McCrea, Jr. , Tatiana Zavorotinskaya , Annette Walter , Pablo Garcia
- 申请人： Matthew Burger , Mika Lindvall , Wooseok Han , Jiong Lan , Gisele Nishiguchi , Cynthia Shafer , Cornelia Bellamacina , Kay Huh , Gordana Atallah , Christopher McBride , William Antonios-McCrea, Jr. , Tatiana Zavorotinskaya , Annette Walter , Pablo Garcia
- 申请人地址： CH Basel
- 专利权人： Novartis AG
- 当前专利权人： Novartis AG
- 当前专利权人地址： CH Basel
- 代理商 Stephen Johnson; Michael Smith
- 国际申请： PCT/US2008/055724 WO 20080303
- 国际公布： WO2008/106692 WO 20080904
- 主分类号： A61K31/4545
- IPC分类号： A61K31/4545 ; C07D401/14
摘要：
New compounds, compositions and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer.
公开/授权文献
- US20120208815A1 PIM KINASE INHIBITORS AND METHODS OF THEIR USE 公开/授权日：2012-08-16
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