A method and a system of setting up a reference signal in a radio communication system. The radio communication system includes a serving cell and a neighboring cell, and a mobile terminal of the serving cell uses the same temporal frequency resource so as to receive a serving resource block from the serving cell and receive an interference resource block from the neighboring cell. The method according to the present disclosure includes a step of setting up a user-specific reference signal in the interference resource block and a step in which puncturing is performed at same temporal frequency position as the temporal frequency position at which the user-specific reference signal is set up on the interference resource block of the serving resource block so as to prevent any signal from being transmitted at the punctured temporal frequency position. When the method and the system provided in the present disclosure are used and the interference power between cells is thereby measured, it is possible to effectively reduce feedback overhead in a coordinated beamforming.