Invention Grant
US08841267B2 Micro-RNA scaffolds, non-naturally occurring micro-RNAs, and methods for optimizing non-naturally occurring micro-RNAs
有权
微RNA支架，非天然存在的微RNA，以及优化非天然存在的微RNA的方法
- Patent Title: Micro-RNA scaffolds, non-naturally occurring micro-RNAs, and methods for optimizing non-naturally occurring micro-RNAs
- Patent Title (中): 微RNA支架，非天然存在的微RNA，以及优化非天然存在的微RNA的方法
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Application No.: US12601506Application Date: 2008-05-22
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Publication No.: US08841267B2Publication Date: 2014-09-23
- Inventor: Melissa Kelley , Amanda Birmingham , Jon Karpilow , Anastasia Khvorova , Kevin Sullivan
- Applicant: Melissa Kelley , Amanda Birmingham , Jon Karpilow , Anastasia Khvorova , Kevin Sullivan
- Applicant Address: US CO Lafayette
- Assignee: GE Healthcare Dharmacon, Inc.
- Current Assignee: GE Healthcare Dharmacon, Inc.
- Current Assignee Address: US CO Lafayette
- Agency: Dorf & Nelson LLP
- Agent Scott D. Locke, Esq.
- International Application: PCT/US2008/064458 WO 20080522
- International Announcement: WO2008/147837 WO 20081204
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C12N15/64 ; C07H21/04
Abstract:
The present disclosure provides non-naturally occurring miR-196a-2 miRNAs and non-naturally occurring miR-204 miRNAs. The non-naturally occurring miRNAs of the disclosure have mature strand sequences distinct from their endogenous counterparts. The disclosure also provides methods of selecting mature strand sequences that function optimally in non-naturally occurring miR-196a-2 miRNAs. The methods and compositions of the disclosure may be used to mediate gene silencing via the RNAi pathway.
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