发明授权
US08841272B2 Double-stranded RNA-based nanoparticles for insect gene silencing
有权
用于昆虫基因沉默的双链RNA基纳米颗粒
- 专利标题： Double-stranded RNA-based nanoparticles for insect gene silencing
- 专利标题（中）： 用于昆虫基因沉默的双链RNA基纳米颗粒
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申请号： US13485181申请日： 2012-05-31
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公开(公告)号： US08841272B2公开(公告)日： 2014-09-23
- 发明人: Kun Yan Zhu , Xin Zhang , Jianzhen Zhang
- 申请人： Kun Yan Zhu , Xin Zhang , Jianzhen Zhang
- 申请人地址： US KS Manhattan
- 专利权人： Kansas State University Research Foundation
- 当前专利权人： Kansas State University Research Foundation
- 当前专利权人地址： US KS Manhattan
- 代理机构： Hovey Williams LLP
- 主分类号： C12N15/11
- IPC分类号： C12N15/11 ; A01N25/00 ; C12N15/113
摘要：
Nanoparticles for insect RNAi via oral delivery are provided, along with methods of silencing a target gene in a target insect using RNAi are provided. The nanoparticles comprise a polymer matrix and insect dsRNA. The dsRNA comprises at least one sequence having a region of complementarity substantially complementary to at least a portion of an mRNA transcript of the target gene. Insect baits comprising the nanoparticles are also provided. Methods of screening target gene functions are also provided using the methods disclosed herein.
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