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公开(公告)号：US20240307552A1
公开(公告)日：2024-09-19
申请号：US18546937
申请日：2022-02-18
发明人： Robert DeLong
IPC分类号： A61K47/69 , A61K38/17 , A61K39/215 , A61K39/385 , A61K48/00
CPC分类号： A61K47/6929 , A61K38/1729 , A61K39/215 , A61K39/385 , A61K48/0033
摘要： The present disclosure provides ZnO-based compositions that stabilize mRNA and RNA as well as provide compositions and therapies to treat or prevent cancer and viral as well as microbial diseases.
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公开(公告)号：US20240307419A1
公开(公告)日：2024-09-19
申请号：US18262970
申请日：2022-01-28
申请人： Kansas State University Research Foundation , Wichita State University , University of Iowa Research Foundation
IPC分类号： A61K31/675 , A61K31/4025 , A61K31/438 , A61P31/12 , C07D207/267 , C07D403/12 , C07F9/6584
CPC分类号： A61K31/675 , A61K31/4025 , A61K31/438 , A61P31/12 , C07D207/267 , C07D403/12 , C07F9/65844
摘要： Compounds and treatment methods with compounds exhibiting antiviral activity and/or inhibition of viral replication against viruses, particularly those belonging to the picornavirus-like supercluster, including coronavirus.
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公开(公告)号：US20240277407A1
公开(公告)日：2024-08-22
申请号：US18044012
申请日：2021-09-03
发明人： Jan Sebek , Punit Prakash , Henky Wibowo
CPC分类号： A61B18/1815 , A61B34/20 , A61B90/37 , A61B90/39 , A61B2018/00023 , A61B2018/00083 , A61B2018/00178 , A61B2018/00577 , A61B2018/00702 , A61B2018/00791 , A61B2018/00886 , A61B2018/1823 , A61B2018/1838 , A61B2018/1846 , A61B2018/1853 , A61B2018/1861 , A61B2090/376 , A61B2090/3966
摘要： Catheter-based applicators incorporating a microwave ablation antenna are provided. The applicator can be flexible and suitable for delivering ablation to target tissues via endoscopic approaches as well as intracavitary/intraluminal approaches. The applicators are configured to create large volume thermal ablation zones with minimal radiation losses along the applicator axis traveling proximal to the ablation zone. This effect is accomplished by employing a backward-facing choke element and/or a multi-slotted antenna having a plurality of spaced-apart conducting elements encircling the antenna.
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公开(公告)号：US12060403B2
公开(公告)日：2024-08-13
申请号：US16756756
申请日：2018-10-16
发明人： Raymond R. R. Rowland , Ana Stoian
IPC分类号： C07K14/705 , A01K67/027 , C12N15/85
CPC分类号： C07K14/705 , A01K67/027 , C12N15/85
摘要： The present disclosure provides compositions and methods for decreasing permissiveness to infection by PRRSV. The methods involve inserting peptides or oligopeptides into the CD163 SRCR domain 5 to disrupt the protein structure and thereby prevent PRRSV infection. The deletion of the exon 13 region of PSTII eliminates infection. The replacement of cysteine residues with alanines in SRCR5 as a means to disrupt disulfide bond formation. The final method is the deletion of, or amino acid substitution within the SRCR4-5 interdomain region.
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公开(公告)号：US20240102995A1
公开(公告)日：2024-03-28
申请号：US18468020
申请日：2023-09-15
IPC分类号： G01N33/53
CPC分类号： G01N33/5308
摘要： The present invention relates in general to the field of rapid detection and quantification of tissue/organ injury, and more particularly, to a novel platform for monitoring and quantification of circulating cell-free DNA including within extracellular vesicles, together with extracellular vesicles specific markers, and extracellular vesicles sizes also in combination with PCR-related technologies in biospecimens, and liquid biopsies for the assessment and prediction of severity of tissue/organ injury, monitoring of disease progression as well as the assessment of the response to therapeutic interventions.
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公开(公告)号：US11771662B2
公开(公告)日：2023-10-03
申请号：US16644776
申请日：2018-09-05
IPC分类号： A61K31/137 , A61P23/00 , A61K31/4196 , A61K31/485 , A61K9/00 , A61K9/08 , A61K31/427 , A61K31/44 , A61K31/451 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/517 , A61K47/10 , A61K47/34
CPC分类号： A61K31/137 , A61K9/0019 , A61K9/0053 , A61K9/08 , A61K31/4196 , A61K31/427 , A61K31/44 , A61K31/451 , A61K31/454 , A61K31/485 , A61K31/496 , A61K31/506 , A61K31/517 , A61K47/10 , A61K47/34 , A61P23/00
摘要： Provided herein are treatments for reducing pain in dogs. The treatments generally comprise a combination of an opioid compound, such as methadone, and an azole compound, such as fluconazole. The treatments may further comprise an opioid abuse deterrent that advantageously inhibits opioid effects in humans while maintaining desirable analgesic effects in dogs. Additionally, the treatments provided herein avoid the undesirable side effects of prior art opioid treatments for dogs. The treatments may be administered as separate doses or in a single formulation product for improved compliance. The treatments have wide use potential in dogs from perioperative patients to inpatients and outpatients and may be used, for example, for sedation in minor procedures, analgesia, and decreasing temperature in canine patients.
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公开(公告)号：US20230292686A1
公开(公告)日：2023-09-21
申请号：US17906657
申请日：2021-03-22
IPC分类号： A01H1/00 , A01H6/46 , C12Q1/6895
CPC分类号： A01H1/1225 , A01H6/4666 , C12Q1/6895 , C12Q2600/13
摘要： Disclosed herein are markers which are associated with chilling tolerance and provide for breeding methods to identify such plants to integrate this trait into cereal plants and further to identify analogous markers in other cereal plants. Importantly, these markers are not linked with deleterious traits such as tall plant height or tannin content, providing for the creation of plant varieties and elite plant varieties with chilling tolerance, dwarf plant height and lack of tannins.
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8.发明公开公开(公告)号：US20230279170A1
公开(公告)日：2023-09-07
申请号：US18177488
申请日：2023-03-02
发明人： Duy H. Hua
CPC分类号： C08F226/10 , B01J35/0013 , B01J37/0072 , B01J23/44 , B01J23/52 , B01J23/72
摘要： Synthesis of chiral polyvinylpyrrolidinone (CSPVP) compounds, complexes of CSPVP with a core species, such as a bimetallic nanocluster catalyst, and selective C—H bond oxidation reactions utilizing such complexes are disclosed. These reaction products can be used as reagents in the synthesis of complex organic molecules, such as bioactive products, and C—H bond oxidation of complex molecules including various drugs and natural products.
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9.发明授权公开(公告)号：US11733149B2
公开(公告)日：2023-08-22
申请号：US16987677
申请日：2020-08-07
CPC分类号： G01N15/1434 , G01N15/0211 , G01N15/06 , G01N2015/0693 , G01N2015/1493
摘要： Apparatus and methods for determining particle size, and optionally, the complex index of refraction for particle suspended in a gas or liquid are provided. The particle to be analyzed is caused to travel through a laser beam having a modified Gaussian profile. The particle causes light from the laser beam to scatter. The scattered light is measured by one or more photodetectors disposed at a particular scattering angle relative to the center of the laser beam. The apparatus and methods can be used in sensors configured to monitor air quality in enclosed environments, such as on-board aircraft and within buildings, and/or detect environmental contaminants.
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10.发明授权公开(公告)号：US11700136B2
公开(公告)日：2023-07-11
申请号：US17296863
申请日：2019-11-21
CPC分类号： H04L9/3278 , H04L9/0662
摘要： A computer-implemented method for authentication of a queried device having an electrical circuit exhibiting physically unclonable functions (PUFs). The method includes: at the queried device, generating a first random number based on an initial first counter value; matching the first random number against a first value of a record stored in a database of a querying device, the record including second (shuffled) and third values; at the queried device, generating a second random number based on a once incremented first counter value, deterministically generating a de-shuffled second value based on an initial second counter value, determining that the second random number matches the de-shuffled second value, and submitting sub-challenges corresponding to the second random number to the electrical circuit to generate a response; and, at the querying device, determining that the response matches the third value of the record to complete a first authentication of the queried device.
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