A method and an apparatus for controlling transmission power in a femto base station is provided. The method includes: predicting femto base station interference to be given from an adjacent femto base station to a terminal; predicting macro base station interference to be given from a macro base station to the terminal; determining transmission power for the terminal; and transmitting a downlink signal to the terminal on the basis of the transmission power, wherein the femto base station interference is predicted on the basis of a distance between serving femto base station and the adjacent femto base station and the transmission power of the adjacent femto base station, and the macro base station interference is predicted on the basis of a distance between serving femto base station and the macro base station and the transmission power of the macro base station.