发明授权
US08846102B2 Non-viral compositions and methods for transfecting gut cells in vivo
有权
用于体内转染肠细胞的非病毒组合物和方法
- 专利标题： Non-viral compositions and methods for transfecting gut cells in vivo
- 专利标题（中）： 用于体内转染肠细胞的非病毒组合物和方法
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申请号： US11694852申请日： 2007-03-30
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公开(公告)号： US08846102B2公开(公告)日： 2014-09-30
- 发明人: Anthony T. Cheung , Eric C. Hsu
- 申请人： Anthony T. Cheung , Eric C. Hsu
- 申请人地址： unknown Vancouver, BC
- 专利权人： enGene, Inc.
- 当前专利权人： enGene, Inc.
- 当前专利权人地址： unknown Vancouver, BC
- 代理机构： Arnold & Porter
- 代理商 Todd Lorenz
- 主分类号： A61K9/50
- IPC分类号： A61K9/50 ; C12N5/071 ; A61K48/00 ; A61K47/36 ; A61K9/51
摘要：
The present invention provides chitosan-based nanoparticles that can protect nucleic acids and deliver the same into gut mucosal cells. Compositions and methods for the expression of therapeutic nucleic acids in cells of the gut mucosa are provided. Compositions and methods for delivering therapeutic proteins systemically from cells of the gut mucosa are also provided.
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